{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:02:39Z","timestamp":1780437759728,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Renal safety is a critical issue in chronic hepatitis B (CHB) patients receiving long\u2010term entecavir (ETV) or tenofovir disofuroxil fumarate (TDF) therapy. We investigated their effects on estimated glomerular filtration rate (eGFR). Treatment\u2010naive CHB patients receiving ETV or TDF for \u22651\u00a0year were recruited. The eGFR was assessed using the Chronic Kidney Disease Epidemiology Collaboration equation. We calculated average annual percent change (AAPC) in eGFR using Joinpoint regression. At the beginning of the observation, the ETV group had more unfavorable conditions than the TDF group: lower eGFR and higher FIB\u20104 and APRI than the TDF group (all\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.001). After 6\u00a0years of antiviral therapy, the mean eGFR in the ETV group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01793) was maintained (96.0 at first year to 95.6\u00a0ml\/min\/1.73\u00a0m\n                    <jats:sup>2<\/jats:sup>\n                    at sixth year; AAPC \u22120.09%;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.322), whereas that in the TDF group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01240) significantly decreased annually (101.9 at first year to 96.9\u00a0ml\/min\/1.73\u00a0m\n                    <jats:sup>2<\/jats:sup>\n                    at sixth year; AAPC \u22120.88%;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.001). Notably, in the TDF group, even patients without diabetes (AAPC \u22120.80%;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001) or hypertension (AAPC \u22120.87%;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.001) experienced significant decrease in eGFR. Expectably, accompanying diabetes (AAPC \u22121.59%;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.011) or hypertension (AAPC \u22121.00%;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.002) tended to accelerate eGFR decrease. TDF treatment (odds ratio 1.66,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.001), along with eGFR&lt;60\u00a0ml\/min\/1.73\u00a0m\n                    <jats:sup>2<\/jats:sup>\n                    , serum albumin&lt;3.5\u00a0mg\/dl, and hypertension, were independently associated with ongoing renal dysfunction, defined as a negative slope of the mean eGFR change. In conclusion, compared with ETV, long\u2010term TDF treatment induced slow, but progressive renal dysfunction. Although the annual eGFR change by TDF was small, careful monitoring is necessary, especially in patients requiring life\u2010long therapy.\n                  <\/jats:p>","DOI":"10.1111\/jvh.13656","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T12:14:13Z","timestamp":1644754453000},"page":"289-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Long\u2010term renal safety between patients with chronic hepatitis B receiving tenofovir vs. entecavir therapy: A multicenter study"],"prefix":"10.1111","volume":"29","author":[{"given":"Young Eun","family":"Chon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cha Bundang Medical Center Cha University Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine School of Medicine Kyungpook National University Kyungpook National University Hospital Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-8050","authenticated-orcid":false,"given":"Seung Up","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital Yonsei University Health System Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Pyo","family":"Hong","sequence":"additional","affiliation":[{"name":"Big Data Center Department of Statistics Yonsei University Wonju College of Medicine Wonju\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-0967","authenticated-orcid":false,"given":"Jae Seung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital Yonsei University Health System Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3552-3560","authenticated-orcid":false,"given":"Hye Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital Yonsei University Health System Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5381-230X","authenticated-orcid":false,"given":"Mi Na","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cha Bundang Medical Center Cha University Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital Yonsei University Health System Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital Yonsei University Health System Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul 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