{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:56:59Z","timestamp":1789581419314,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["2018\u20130297"],"award-info":[{"award-number":["2018\u20130297"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic hepatitis C virus (HCV) infection is associated with neuropsychiatric changes. Also, patients with cirrhosis may develop overt or minimal hepatic encephalopathy. Sustained virological response (SVR) with direct\u2010acting antiviral agents (DAAs) may improve the neuropsychiatric manifestations and quality of life (QoL). Consecutive patients (with and without cirrhosis, all genders and aged 18\u201365\u00a0years) with hepatitis C were assessed at enrolment and at 12\u00a0weeks after therapy completion for mood (Beck's Depression Inventory [BDI]), anxiety (generalized anxiety disorder [GAD\u20107]), QoL (SF\u201036 ver.2) and computer\u2010based tests for number connection (NCT), visual memory, Stroop test and reaction times. We recruited 385 viraemic chronic HCV patients (76.1% male, 21.0% cirrhotic, mean age 39.4\u00a0\u00b1\u00a014.2\u00a0years, 59.3% genotype 3, mean HCV RNA load 5.8\u00a0log). Overall SVR\u201012 rates were 90.6%, with cure rates 87.6% and 91.4% in patients with and without cirrhosis, respectively. Patients who achieved SVR\u201012\u00a0had mean percentage reduction in BDI (11.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.000), GAD (8.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) and Stroop test (58.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), with improved NCT (1.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), visual memory (13.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) and digit span (23.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002). On multivariate logistic regression, adherence (OR, 17.5 [95% CI 2.80\u2013110.50], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.000), high ALT (OR 1.02 [95% CI 1.00\u20131.05]), and BDI score (OR 1.73 [95% CI 1.42\u20133.26] <jats:italic>p<\/jats:italic>\u00a0=\u00a0.039) predicted cure. SVR\u201012 was associated with improved visual memory \u22655.5 (AUC\u20100.708; sensitivity 62.5%, specificity 63%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.000) and % correct Stroop test responses &gt;26.6% (AUC\u20100.918, sensitivity 94.4% specificity 80.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.000). In conclusion, given the cumulative evidence of the safety of DAAs and efficacy of improving cognitive and neuropsychological and quality\u2010of\u2010life outcomes irrespective of age and gender, as shown in our study, future recommendations should focus on integrated universal HCV care to enable HCV elimination.<\/jats:p>","DOI":"10.1111\/jvh.13668","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T13:19:52Z","timestamp":1646918392000},"page":"395-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Improvement of chronic HCV infection\u2010related depression, anxiety, and neurocognitive performance in persons achieving SVR\u201012: A real\u2010world cohort study"],"prefix":"10.1111","volume":"29","author":[{"given":"Harmanpreet","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  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