{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T15:29:07Z","timestamp":1769959747250,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008075","name":"Pinngortitaleriffik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008075","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In\u2010depth reviewing of all medical records and clinical databases concluded a 7\u2010year shorter lifespan among Greenlanders infected with hepatitis B virus (HBV) compared with non\u2010infected. Mortality did not associate with liver disease or any other specific disease entity. A possible mechanism for the reduced lifespan is subclinical inflammation that may be augmented by chronic viral infection. We hypothesized that chronic HBV infection contributes to this process causing a reduced life span. We added measurement of two markers of inflammation to the 10\u2010year follow\u2010up on our study of HBV among 50\u2010 through 69\u2010years\u2010old subjects in Greenland. The markers were YKL40 related to liver disease and hsCRP as a global marker of inflammation. Survival was evaluated using Cox regression with time until death entered as dependent variable and age, sex, smoking, alcohol intake, BMI, the presence of HBsAg and one marker of inflammation as explanatory variables. Forty\u2010eight percent of participants with chronic HBV infection were alive after 10\u00a0years compared with 65% of participants without infection (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.003). Survival associated with age (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001), BMI (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.003) and both YKL40 and hsCRP (both, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). Harbouring HBV influenced 10\u2010year survival in the Cox regression after adjusting for age, sex, BMI, smoking, alcohol intake and inflammation. In conclusion, chronic low\u2010grade inflammation and being infected with HBV were independent markers of mortality in otherwise healthy subjects. Thus, the 7\u2010year shorter lifespan among Greenlanders with chronic HBV infection seems related to the long\u2010lasting infection. Our findings call for caution in perceiving a chronic infection as benign.<\/jats:p>","DOI":"10.1111\/jvh.13673","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T15:48:20Z","timestamp":1648741700000},"page":"432-437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mortality in Greenlanders with chronic hepatitis B virus infection"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5294-2428","authenticated-orcid":false,"given":"Henrik B.","family":"Krarup","sequence":"first","affiliation":[{"name":"Department of Molecular Diagnostics Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten F.","family":"Rex","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Queen Ingrid\u2019s Hospital  Nuuk Greenland"},{"name":"Arctic Health Research Centre Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stig","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Internal Medicine Queen Ingrid\u2019s Hospital  Nuuk Greenland"},{"name":"Arctic Health Research Centre Aalborg University Hospital  Aalborg Denmark"},{"name":"Greenland Institute for Health Research Ilisimatusarfik Greenland University  Nuuk Greenland"},{"name":"Department of Geriatric Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701712198"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i9.1265"},{"key":"e_1_2_7_4_1","volume-title":"Hepatitis among Greenlanders in Denmark and in Greenland, and the outcome of chronic HBV\u2010infection in Greenland [Ph.D.]","author":"Rex 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