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As aged individuals comprise a large percentage of HCV\u2010infected patients, the effectiveness and safety of DAAs in the elderly have come under scrutiny. This meta\u2010analysis aimed to evaluate the efficacy and safety of DAAs in elderly patients. After a systematic search in PubMed (MEDLINE), Embase, OVID MEDLINE, the Cochrane Library and other databases, two investigators reviewed relevant abstracts and selected manuscripts for examination. The sustained virologic response (SVR) and adverse event (AE) rates were calculated with a random\u2010effects model. Ninety studies evaluating SVR rates of elderly patients (\u226565\u00a0years old) receiving DAAs were selected. DAAs in elderly patients exhibited a notable SVR rate of 96% (95% confidence interval [CI]: 95%\u201397%), accompanied by comparable rates in subgroup analyses. The comparison of SVR rates in elderly and non\u2010elderly patients indicated no significant discrepancy (odds ratio [OR] 1.01, 95% CI: 1.00\u20131.01). The overall event rate of AEs was 45% (95% CI: 31%\u201360%), though AE rates varied by subgroups. Furthermore, AEs were comparatively more frequent (OR 1.15, 95% CI: 1.04\u20131.28) in the elderly than non\u2010elderly, especially in subgroups such as SAE (OR 1.89, 95% CI: 1.52\u20132.36) and dose reduction in ribavirin (OR 1.90, 95% CI: 1.53\u20132.36). However, in the ribavirin (RBV)\u2010free regimen, there was no significant difference in the incidence of AEs between the elderly and non\u2010elderly groups. DAAs have high efficacy in elderly patients. Considering the possibility of AE, the RBV\u2010free regimen should be given prior consideration for the treatment of elderly patients with HCV.<\/jats:p>","DOI":"10.1111\/jvh.13679","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T15:57:11Z","timestamp":1648742231000},"page":"496-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of direct\u2010acting antiviral therapy for hepatitis C virus in elderly patients (\u226565\u00a0years old): A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Jieun","family":"Lee","sequence":"first","affiliation":[{"name":"College of Medicine Soonchunhyang University  Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Bong","family":"Ahn","sequence":"additional","affiliation":[{"name":"Nowon Eulji Medical Center Department of Internal Medicine Eulji University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Young","family":"Yim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihyun","family":"An","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Hanyang University College of Medicine  Guri Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Won","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jung","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Healthcare Technology Assessment Research National Evidence\u2010based Healthcare Collaborating Agency (NECA)  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Ah","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Healthcare Technology Assessment Research National Evidence\u2010based Healthcare Collaborating Agency (NECA)  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-0381","authenticated-orcid":false,"given":"Jeong\u2010Ju","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Soonchunhyang University Bucheon Hospital  Bucheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30349-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.3.47"},{"key":"e_1_2_10_4_1","volume-title":"Global Health Sector Strategy on Viral Hepatitis 2016\u20132021. 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