{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:40:45Z","timestamp":1775072445989,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In 2014, an analysis was conducted to evaluate the hepatitis C virus (HCV) epidemiology and disease burden in Germany. Since then, there have been considerable developments in HCV management such as the implementation of direct acting antivirals. The aim of this analysis was to assess the recent data available for Germany, establish an updated 2020 HCV prevalence and cascade of care and evaluate the impact of what\u2010if scenarios on the future burden of disease using modelling analysis. A dynamic Markov model was used to forecast the HCV disease burden in Germany. Model inputs were retrieved through literature review, unpublished sources and expert input. Next, three \u201cwhat\u2010if\u201d scenarios were developed to evaluate the status quo, COVID\u201019 pandemic, and steps needed to achieve the WHO targets for elimination. At the beginning of 2020, there were 189,000 (95% UI: 76,700\u2013295,000) viremic infections in Germany, a decline of more than 85,000 viremic infections since 2012. Annual treatment starts went down since 2015. Compared with 2019, the COVID\u201019 pandemic resulted in a further 11% decline in 2020. If this continues for two years, it could result in 110 excess HCC cases and 200 excess liver related deaths by 2030. To achieve the WHO targets, 81,200 people need to be diagnosed, with 118,600 initiated on treatment by 2030. This could also avert 1,020 deaths and 720 HCC cases between 2021 and 2030. Germany has made strides towards HCV elimination, but more efforts are needed to achieve the WHO targets by 2030.<\/jats:p>","DOI":"10.1111\/jvh.13680","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T15:55:29Z","timestamp":1648742129000},"page":"536-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Updated epidemiology of hepatitis C virus infections and implications for hepatitis C virus elimination in Germany"],"prefix":"10.1111","volume":"29","author":[{"given":"Tammo L.","family":"Tergast","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Blach","sequence":"additional","affiliation":[{"name":"CDA Foundation  Lafayette Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Tacke","sequence":"additional","affiliation":[{"name":"Department of Hepatology &amp; Gastroenterology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Virchow\u2010Klinikum and Campus Charit\u00e9 Mitte  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Berg","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Medicine II Leipzig University Medical Center  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-8001","authenticated-orcid":false,"given":"Markus","family":"Cornberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School  Hannover Germany"},{"name":"Leberstiftungs\u2010GmbH Deutschland  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Kautz","sequence":"additional","affiliation":[{"name":"Kautz5 gUG  K\u00f6ln Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Manns","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School  Hannover Germany"},{"name":"Leberstiftungs\u2010GmbH Deutschland  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homie","family":"Razavi","sequence":"additional","affiliation":[{"name":"CDA Foundation  Lafayette Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Sarrazin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Center St. Josefs\u2010Hospital Wiesbaden  Wiesbaden Germany"},{"name":"Viral Hepatitis Research Group Goethe\u2010University Hospital Frankfurt  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6263-0230","authenticated-orcid":false,"given":"Yvonne","family":"Serfert","sequence":"additional","affiliation":[{"name":"Leberstiftungs\u2010GmbH Deutschland  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"van Thiel","sequence":"additional","affiliation":[{"name":"Deutsche Leberhilfe  K\u00f6ln Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Zeuzem","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School  Hannover Germany"},{"name":"Leberstiftungs\u2010GmbH Deutschland  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12249"},{"key":"e_1_2_8_3_1","volume-title":"Epidemiological Bulletin 30\/31 2020. 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