{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:30:07Z","timestamp":1762432207985},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Data on hepatitis B virus (HBV) pregenomic (pgRNA) levels in HIV\/HBV coinfected patients pre\u2010 and post\u2010combined antiretroviral therapy (cART) are limited. This study aimed to evaluate the distribution of HBV pgRNA levels in treatment\u2010naive coinfected patients and explore the changes that occur after the initiation of cART by examining patients from multicentre cohort studies performed in China. We included HIV\/HBV coinfected subjects from the China AIDS Clinical Trial cohorts established from 2008 to 2014. Clinical and serological markers of HIV and HBV infection and biochemical data were acquired at baseline and after 96 and 240\u2013480\u2009weeks of cART. The correlations between HBV pgRNA and HBV DNA levels as well as HBsAg levels were calculated using Spearman's bivariate correlation analysis, and multivariate regression analysis was performed to determine factors associated with undetectable HBV pgRNA levels before cART and HBeAg loss after cART. A total of 132 HIV\/HBV coinfected patients were enrolled, and 100 individuals were HBeAg\u2010negative. A total of 34.4% (32\/93) of patients were positive for HBV pgRNA, and the median HBV pgRNA level was 4.92 (IQR: 4.21\u20136.12) log<jats:sub>10<\/jats:sub> copies\/mL before cART. The median HBV pgRNA level was significantly lower in HBeAg\u2010negative individuals than in HBeAg\u2010positive individuals (4.22 (IQR: 2.70\u20134.84) log<jats:sub>10<\/jats:sub> copies\/mL vs. 5.77 (IQR: 4.63\u20136.55) log<jats:sub>10<\/jats:sub> copies\/mL, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). HBV pgRNA was moderately correlated with HBsAg (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.594, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), and positively associated with HBV DNA (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.445, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011). The factors independently associated with undetectable HBV pgRNA level before cART were HBV DNA (OR: 5.61, 95% CI: 1.50\u201320.96, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) and HBeAg status (OR: 5.95, 95% CI: 1.52\u201323.25, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). A total of 87.5% (28\/32) of patients were followed for a median duration of 138 (IQR: 54\u2013240) weeks, and the HBV pgRNA levels became undetectable in seven patients. The 132 patients were observed for 695.5 person\u2010years, and no HBsAg loss occurred. Thirteen individuals achieved HBeAg loss, four patients had undetectable levels of HBV pgRNA pre\u2010cART, and the level of six individuals became undetectable during the 48\u2010week (IQR: 48\u2013264) follow\u2010up period. HBeAg status was significantly associated with HBV pgRNA level in HIV\/HBV coinfected patients pre\u2010 and post\u2010cART. Additionally, undetectable HBV pgRNA level may be associated with HBeAg loss after cART.<\/jats:p>","DOI":"10.1111\/jvh.13704","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T07:33:22Z","timestamp":1652859202000},"page":"616-626","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>HBV pgRNA<\/scp> profiles in Chinese <scp>HIV<\/scp>\/<scp>HBV<\/scp> coinfected patients under pre\u2010 and posttreatment: a multicentre observational cohort study"],"prefix":"10.1111","volume":"29","author":[{"given":"Ling","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Center for AIDS Research Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Chao\u2010yang Hosipital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Center for AIDS Research Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianfeng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Center for AIDS Research Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaosheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Center for AIDS Research Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Center for AIDS Research Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Center for AIDS Research Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Center for AIDS Research Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Center for AIDS Research Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Center for AIDS Research Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Tsinghua University Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1170"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.19.1.20659"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11913-1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001574"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000927"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002386"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hep.2003.09.022"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31616"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2017.12.016"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-0966-4"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-021-01780-5"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.029"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00183-09"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02124-09"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2020.198117"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1904398"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1909512"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13299"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2015.06.008"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26529"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29872"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13425"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13227"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25612"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13704","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvh.13704","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T13:31:13Z","timestamp":1692883873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,7]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jvh.13704"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13704","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,7]]},"assertion":[{"value":"2022-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}