{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T14:00:40Z","timestamp":1773496840149,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T00:00:00Z","timestamp":1654300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis C virus infection (HCV) is common, and injecting drug use is the major risk factor for acquisition. Understanding HCV reinfection following treatment is an important consideration for HCV elimination programmes. The aim of this work was to assess the frequency and patterns of HCV reinfection in our region to develop avoidance strategies. All individuals who completed anti\u2010HCV treatment with a known outcome in Tyne and Wear, England between January 2016 and May 2021 were included. This was a retrospective analysis of prospectively collected data. HCV reinfection was defined as positive HCV RNA after achieving sustained virological response 12 (SVR12). 788 of 840 patients (76% male; mean age 45.7\u2009\u00b1\u200911.9\u2009years; 47% Genotype 1; 11% Cirrhosis; 20% started in prison) achieved SVR (94%). 443 patients (56%) had HCV RNA testing post\u2010SVR after a median 0.82 (range 0.1\u20135.2) years. 56 reinfections (7.1% of all SVRs and 12.6% of SVRs who had post\u2010SVR testing) were diagnosed. The median time to reinfection was 1.37 (range 0.1\u20134.0) years and the rate of reinfection was 10.5 \/100 person years. 45 (80%) reinfections became chronic, 17 of whom were retreated and achieved SVR. 5 individuals developed a second reinfection. Younger age was the only factor independently associated with reinfection (HR 0.91 [0.88\u20130.94] <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). In conclusion, HCV reinfection is common and may slow our HCV elimination efforts. In order to address high reinfection rates, harm minimization approaches need improved, and we have implemented an \u2018HCV track and trace\u2019 pilot to try to reduce onwards HCV transmission.<\/jats:p>","DOI":"10.1111\/jvh.13707","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T13:04:26Z","timestamp":1653829466000},"page":"685-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Determining the frequency and characteristics of Hepatitis C reinfections in North East England"],"prefix":"10.1111","volume":"29","author":[{"given":"Sumar","family":"Askar","sequence":"first","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Jelley","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"McQue","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Allsop","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"McCullough","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Miller","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusri","family":"Taha","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"},{"name":"Department of Microbiology and Virology Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Masson","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"},{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"McPherson","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"},{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,4]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO.Hepatitis C fact sheet. World Health Organisation. 2021."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.27831"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2020-000470"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-017-9440-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30227-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.02666"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27766"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13900"},{"key":"e_1_2_9_12_1","unstructured":"WHO.Global health sector strategy on viral hepatitis 2016\u20102021. 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