{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:23:16Z","timestamp":1772594596782,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic hepatitis C virus (HCV) infection is major cause of decompensated cirrhosis and liver cancer. The advent of curative new antiviral therapies since year 2015 has dramatically improved the prognosis of HCV patients. The real\u2010life clinical benefits at country level of these therapies have not yet been assessed. This is a retrospective study of all hospitalizations in Spain including HCV as diagnosis using the Spanish National Registry of Hospital Discharges. Information was retrieved from 1997 to 2019. From 81,482,509 nationwide hospital admissions recorded during the study period, 1,057,582 (1.29%) included HCV as diagnosis. The median age of HCV hospitalized patients was 54\u2009years old. Males accounted for 63.2% of cases. Most HCV admissions recorded chronic hepatitis C whereas acute hepatitis C was reported in less than 3%. In\u2010hospital death occurred in 6.4% of HCV admissions. Coinfection with HIV or hepatitis B virus was seen in 14.8% and 6.4%, respectively. Patients hospitalized with HIV\u2010HCV coinfection represented 14.8% of cases and were on average 17\u2009years younger than HCV\u2010monoinfected individuals. The rate of HCV hospitalizations significantly increased until 2005, and then stabilized for one decade. A significant reduction was noticed since 2015. However, whereas the proportion of HCV\u2010associated hepatic decompensation events declined since then, liver cancer diagnoses increased. In conclusion, hospital admissions of HCV individuals significantly declined in Spain since 2015 following a wide prescription of new oral direct\u2010acting antivirals. This reduction was primarily driven by a fall of hepatic decompensation events whereas HCV\u2010related liver cancer continues rising.<\/jats:p>","DOI":"10.1111\/jvh.13708","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T13:05:00Z","timestamp":1653829500000},"page":"777-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hepatitis C hospitalizations in Spain and impact of new curative antiviral therapies"],"prefix":"10.1111","volume":"29","author":[{"given":"Jos\u00e9\u2010Manuel","family":"Ramos\u2010Rincon","sequence":"first","affiliation":[{"name":"Internal Medicine Department General University Hospital of Alicante\u2010ISABIAL &amp; Miguel Hern\u00e1ndez University of Elche  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Pinargote\u2010Celorio","sequence":"additional","affiliation":[{"name":"Internal Medicine Department General University Hospital of Alicante\u2010ISABIAL &amp; Miguel Hern\u00e1ndez University of Elche  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-7492","authenticated-orcid":false,"given":"Carmen","family":"de Mendoza","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine Puerta de Hierro Research Institute &amp; University Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Ramos\u2010Belinch\u00f3n","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Gregorio Mara\u00f1\u00f3n University Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Barreiro","sequence":"additional","affiliation":[{"name":"Public Health Laboratory Hospital Isabel Zendal  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"G\u00f3mez\u2010Gallego","sequence":"additional","affiliation":[{"name":"UNIR Health Sciences School &amp; Medical Center  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Octavio","family":"Corral","sequence":"additional","affiliation":[{"name":"UNIR Health Sciences School &amp; Medical Center  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-5199","authenticated-orcid":false,"given":"Vicente","family":"Soriano","sequence":"additional","affiliation":[{"name":"UNIR Health Sciences School &amp; Medical Center  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32320-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.08.018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.7085"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2017.1346609"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00218-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1810477"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30270-X"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0332-6"},{"key":"e_1_2_9_10_1","unstructured":"Grupo de trabajo del estudio de prevalencia de la infecci\u00f3n por hepatitis C en poblaci\u00f3n general en Espa\u00f1a; 2017\u20102018. 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