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We used nationwide registers to identify persons aged \u226518\u2009years with chronic HBV infection in 2002\u20132017 in Denmark and included 10 age\u2010 and sex\u2010matched controls for each. Follow\u2010up was from 6\u00a0months after diagnosis until death, emigration, or 31 December 2017. Mortality rate ratios (MRRs) adjusted for age, sex, employment, origin and comorbidity were calculated using Poisson regression. Unadjusted cause\u2010specific mortality rate ratios with 95% confidence intervals were calculated assuming a Poisson distribution. A total of 6988 persons with chronic HBV infection and 69,847 controls were included. During a median follow\u2010up of 7.7\u2009years (range 0.0\u201315.5), 315 (5%) persons with\u2014and 1525 (2%) without\u2014chronic HBV infection died. The adjusted all\u2010cause MRR was 1.5 (95% CI 1.2\u20132.0). Persons with chronic HBV infection had increased mortality due to liver disease including hepatocellular carcinoma (MRR 12.3 [8.6\u201317.7]), external causes (MRR 3.3 [2.5\u20134.7]), endocrine disease (MRR 3.2 [1.8\u20135.4]), genitourinary disease (MRR 3.2 [1.2\u20137.6]) and neoplasms (except hepatocellular carcinoma; MRR 1.6 [1.2\u20132.0]). In conclusion, this study showed an increased all\u2010cause mortality in persons with chronic HBV infection in comparison with age\u2010 and sex\u2010matched persons without chronic HBV infection which remained after adjustment for several confounding factors. Excess mortality was mainly associated with liver disease, but also external factors, endocrine disease, genitourinary disease and neoplasms (excluding hepatocellular carcinoma).<\/jats:p>","DOI":"10.1111\/jvh.13713","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T06:54:29Z","timestamp":1653720869000},"page":"727-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mortality and cause of death in persons with chronic hepatitis B virus infection versus healthy persons from the general population in Denmark"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-4582","authenticated-orcid":false,"given":"Signe","family":"Bollerup","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital  Hvidovre 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