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Using modelling, we estimated the impact of targeted antiviral treatment scale\u2010up and changes in migration on HBV\u2010related mortality and HBV elimination in CALD populations in Australia. We fitted a deterministic mathematical model based on the natural history of HBV and the Australian migration effect in four CALD population groups according to country of birth. We used three antiviral treatment scale\u2010up scenarios: <jats:italic>baseline<\/jats:italic> (9.3% coverage); <jats:italic>intermediate<\/jats:italic> (coverage of 80% of patients eligible for antiviral therapy by 2030); and <jats:italic>optimistic<\/jats:italic> (coverage of 20% of all patients living with HBV by 2022). Our model predicted that if the <jats:italic>baseline<\/jats:italic> treatment is followed between 2015 and 2030, the number of chronic HBV cases and HBV\u2010related mortality will increase. Following the <jats:italic>optimistic<\/jats:italic> scale\u2010up, the number of new HBV cases could be reduced by 78%, 73%, 74% and 83% in people born in Asia\u2010Pacific, Europe, Africa and the Middle East, and Americas, respectively, between 2015 and 2030. An <jats:italic>optimistic<\/jats:italic> treatment scale\u2010up could result in a 19.2%\u201324.5% reduction in HBV\u2010related mortality and a 15%\u201325% reduction in HCC\u2010related mortality in CALD populations between 2015 and 2030. In conclusion, our findings highlight that targeted antiviral treatment for CALD populations provides significant health system benefits by reducing HBV\u2010related complications from cirrhosis and HCC. Expanded antiviral treatment programmes focusing on high\u2010prevalence CALD populations may be an effective strategy to reduce HBV\u2010related morbidity and mortality.<\/jats:p>","DOI":"10.1111\/jvh.13727","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T13:14:32Z","timestamp":1656076472000},"page":"868-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Targeted antiviral treatment of hepatitis B virus in culturally and linguistically diverse populations to achieve elimination targets in Australia"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2659-1059","authenticated-orcid":false,"given":"Belaynew W.","family":"Taye","sequence":"first","affiliation":[{"name":"Faculty of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Mater Research Institute\u2010University of Queensland  Brisbane Queensland Australia"},{"name":"Population Health QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"Department of Epidemiology Bahir Dar University  Bahir Dar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia C.","family":"Valery","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Population Health QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Clark","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Mater Research Institute\u2010University of Queensland  Brisbane Queensland Australia"},{"name":"Population Health QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"Department of Gastroenterology and Hepatology Mater Hospitals  Brisbane Queensland Australia"},{"name":"Department of Gastroenterology and Hepatology Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v6.i13.589"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization.Hepatitis B.2021. 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