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A total of 1384 patients who achieved SVR (714, interferon\u2010based therapy; 670, direct\u2010acting antiviral therapy) were enrolled. Factors associated with HCC development were analysed within and beyond 10\u2009years after SVR by Cox proportional hazards models. The annual incidence rates of HCC development were 0.568% within 10\u2009years after SVR and 0.190% beyond 10\u2009years, and there was a significant difference in the incidence of HCC development between the 2 periods (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0242, log\u2010rank test). Male gender (adjusted hazard ratio [aHR] 2.930; 95% confidence interval [CI] 1.508\u20135.693, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0015), fibrosis\u20104 (FIB\u20104) score\u2009&gt;\u20093.25 (aHR 4.364; 95%CI 2.206\u20138.633, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and alpha\u2010fetoprotein \u22655.0\u00a0ng\/ml (aHR 2.381; 95%CI 1.325\u20134.280, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0037) were independently associated with HCC development within 10\u2009years after SVR. Male gender (aHR 4.702; 95%CI 1.366\u201316.190, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0141), presence of diabetes mellitus (aHR 2.933; 95%CI 1.240\u20136.935, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0143) and gamma\u2010glutamyl transpeptidase (GGT)\u2009\u2265\u200956\u2009U\/l (aHR 4.157; 95%CI 1.400\u201312.350, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0103) were independently associated with HCC development beyond 10\u2009years after SVR. The incidence of HCC development beyond 10\u2009years after SVR was very low, and the associated factors were mainly extrahepatic, including DM and elevated GGT. Annual routine check\u2010ups with abdominal ultrasound may be sufficient for such patients. (242 words).<\/jats:p>","DOI":"10.1111\/jvh.13728","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T13:39:22Z","timestamp":1657028362000},"page":"919-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Factors linked to hepatocellular carcinoma development beyond 10\u2009years after viral eradication in patients with hepatitis C virus"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-495X","authenticated-orcid":false,"given":"Takashi","family":"Kumada","sequence":"first","affiliation":[{"name":"Department of Nursing Gifu Kyoritsu University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-6168","authenticated-orcid":false,"given":"Hidenori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital  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