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In the current study, we aimed to identify risk factors for HCV infection in an ED population. We performed a retrospective analysis of ED patients\u2009\u2265\u200918\u2009years who were screened for HCV between 28 November 2018, and 27 November 2019, at a single urban, quaternary referral academic hospital. An HCV\u2010antibody immunoassay (HCV\u2010Ab) was used for screening; positive results were confirmed by measuring HCV ribonucleic acid (RNA). The outcome of interest was the number of new HCV diagnoses (presence of viremia by HCV RNA testing). Multiple logistic regression models were used to identify risk factors associated with a new HCV diagnosis. 16,722 adult patients were screened for HCV (mean age: 46\u2009\u00b1\u200915\u2009years; 51% female). HCV seroprevalence was 5%. Independent risk factors for HCV included increasing age [10\u2010year aOR 1.26 (95% CI 1.23, 1.30)], male sex [aOR 1.25 (95% CI 1.03, 1.51)], undomiciled housing status [aOR 2.8 (95% CI 2.3, 3.5)], history of tobacco use [aOR 3.0 (95% CI 2.3, 3.9)], history of illicit drug use [aOR 3.6 (95% CI 2.9, 4.5)], Medicaid insurance status [aOR 4.0 (95% CI 2.9, 5.5)] and Medicare insurance status [aOR 1.6 (95% CI 1.1, 2.2)].The ED services a high\u2010risk population with regards to HCV infection. These data support universal screening of ED patients for HCV. Risk factor profiles could improve targeted screening at institutions without universal testing protocols.<\/jats:p>","DOI":"10.1111\/jvh.13730","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T18:16:49Z","timestamp":1657045009000},"page":"930-937","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk factors for hepatitis C virus infection at a large urban emergency department"],"prefix":"10.1111","volume":"29","author":[{"given":"James S.","family":"Ford","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Hollywood","sequence":"additional","affiliation":[{"name":"A.T. 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