{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:17:45Z","timestamp":1770815865649,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis B virus e antigen (HBeAg) loss and the appearance of antibodies to HBeAg (anti\u2010HBe) are favourable events in the history of chronic hepatitis B virus (CHB) infection. Most CHB patients have the HBeAg\/anti\u2010HBe profiles +\/\u2212 or \u2212\/+, and little is published on the derivation or fate of the +\/+ and \u2212\/\u2212 profiles. We have used electronically accessible patient data to study the HBeAg and anti\u2010HBe profiles of a multi\u2010ethnic cohort of adult HBV patients seen at a single centre over a period of more than 20\u2009years. 3594 HBsAg\u2010positive patients were identified and patients with viral coinfection or acute HBV infection were excluded. Cross\u2010sectional and longitudinal analyses of HBeAg\/anti\u2010HBe status were undertaken. Compared with White or Black patients, Chinese and Asian patients are more likely to be HBeAg positive during child\u2010bearing years. Patients with +\/+ profile are likely to undergo HBeAg loss and seroconversion during relatively short follow\u2010up. Chinese patients have a relatively increased rate of seroconversion. For HBeAg\u2010positive patients, the risk of seroconversion diminishes with advancing age. Despite HBeAg loss, seroconversion is seldom observed after age 60\u2009years. The proportion of HBV patients with \u2212\/\u2212 increases with age, and most acquire this profile by HBeAg loss but without antecedent seroconversion. \u2212\/\u2212 patients can lose HBsAg and develop anti\u2010HBs. It was not possible to demonstrate a favourable impact of antiviral treatment on the rate of HBeAg seroconversion.<\/jats:p>","DOI":"10.1111\/jvh.13731","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T11:32:04Z","timestamp":1657107124000},"page":"879-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hepatitis B e antigen and e antibody in a multi\u2010ethnic cohort of adult chronic hepatitis B virus patients followed at a single liver unit for a period of 20\u2009years"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6648-7446","authenticated-orcid":false,"given":"David","family":"Mutimer","sequence":"first","affiliation":[{"name":"Liver and Hepatobiliary Unit, Queen Elizabeth Hospital University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"},{"name":"Institute of Immunology and Immunotherapy College of Medical and Dental 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