{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:46:41Z","timestamp":1791283601217,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1302000"],"award-info":[{"award-number":["2021YFA1302000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1103000"],"award-info":[{"award-number":["2021YFA1103000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515011632"],"award-info":[{"award-number":["2019A1515011632"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170612"],"award-info":[{"award-number":["82170612"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672701"],"award-info":[{"award-number":["81672701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070611"],"award-info":[{"award-number":["82070611"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873572"],"award-info":[{"award-number":["81873572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173064"],"award-info":[{"award-number":["82173064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971481"],"award-info":[{"award-number":["81971481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is unclear whether hepatitis B surface antibody (HBsAb) confers clinical benefits after HBsAg seroclearance, especially in hepatitis B surface antigen (HBsAg) seroreversion and maintenance of HBsAb. We evaluated this in patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0222) with HBsAg loss following treatment with pegylated interferon (PEG\u2010IFN)\u2010based therapy who completed a 48\u2010week follow\u2010up period. Serum hepatitis B virus (HBV) markers and biochemical indicators were evaluated every 3\u00a0months. The primary endpoint was HBsAg seroreversion. Factors associated with HBsAg seroreversion were also investigated. HBsAb \u2265100\u2009mIU\/ml resulted in a lower HBsAg seroreversion rate than an HBsAb\u2010negative status (5.5% vs. 29.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001); however, the seroreversion rate was not significantly different between patients with HBsAb 10\u2013100\u2009mIU\/ml and those in the HBsAb\u2010negative group. Patients with HBsAb \u2265100\u2009mIU\/ml had a lower HBsAb loss rate than those with HBsAb 10\u2013100\u2009mIU\/ml (7.3% vs. 21.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005). The final HBsAg seroreversion and HBV DNA relapse rates were 13.5% and 1.8%, respectively. HBsAb \u2265100\u2009mIU\/ml at the off\u2010treatment time (odds ratio [OR] 0.110, 95% confidence interval [CI]: 0.034\u20130.353, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and treatment time to attain HBsAg loss &gt;28\u2009weeks (OR 2.508, 95% CI: 1.068\u20135.890, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.035) were predictors of HBsAg seroreversion. Consolidation therapy for 12\u201324\u2009weeks resulted in higher HBsAb titres than consolidation therapy for \u226412\u2009weeks in HBsAb\u2010negative patients at the off\u2010treatment time (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). HBsAg seroconversion with HBsAb \u2265100\u2009mIU\/ml decreases HBsAg seroreversion and provides an efficient maintenance rate of HBsAb. HBsAg seroconversion with high HBsAb titres may be clinically beneficial for chronic hepatitis B treated with PEG\u2010IFN\u2010based therapy.<\/jats:p>","DOI":"10.1111\/jvh.13734","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:34:31Z","timestamp":1658709271000},"page":"899-907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Role of hepatitis B surface antibody in seroreversion of hepatitis B surface antigen in patients achieving hepatitis B surface antigen loss with pegylated interferon\u2010based therapy"],"prefix":"10.1111","volume":"29","author":[{"given":"Na","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou Guangdong 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Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control (Sun Yat\u2010sen University), Ministry of Education  Guangzhou Guangdong 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