{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:37:59Z","timestamp":1782862679432,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis delta virus (HDV) infection is associated with accelerated progression of liver disease to cirrhosis. Shear wave elastography (SWE) is a non\u2010invasive evaluation method of liver fibrosis. Its performance in accurately characterizing HDV fibrosis compared to other noninvasive markers remains unknown. We assessed the performance of SWE in patients with chronic HDV, Hepatitis B (HBV) and Hepatitis C (HCV) infection. Cirrhosis was determined by histology or clinical data. Area under receiver operator characteristics (AUROC) was used to assess diagnostic performance in identifying cirrhosis by SWE in comparison with Fibroscan\u00ae (VCTE) and serologic tests of fibrosis. 158 patients with chronic hepatitis (HDV:44%, HBV: 46% and HCV: 29%) were evaluated. Cirrhosis was diagnosed in 28 (17.7%) patients. Mean noninvasive fibrosis measurements for the HBV\/HCV and HDV groups, respectively, were as follows: APRI: 0.73\u2009\u00b1\u20091.08 and 1.3\u2009\u00b1\u20091.38; FIB\u20104: 1.90\u2009\u00b1\u20092.24 and 2.33\u2009\u00b1\u20092.24; VCTE: 8.9\u2009\u00b1\u20096.7\u00a0kPa vs 10.4\u2009\u00b1\u20095.3\u00a0kPa; SWE: 1.5\u2009\u00b1\u20090.2\u00a0m\/s and 1.6\u2009\u00b1\u20090.2\u00a0m\/s. The performance of SWE in detecting HDV\u2010induced cirrhosis (AUROC 0.84, 95% CI 0.71\u20130.97) was slightly lower than in HBV\/HCV induced disease (AUROC 0.88, 95% CI 0.81\u20130.96). For HDV patients, the performance of SWE was comparable to VCTE and slightly better than APRI and FIB\u20104 especially in APRI and FIB\u20104 indeterminate zones. The overall less accurate performance of noninvasive markers in HDV in comparison with HBV and HCV may be a result of significant hepatic inflammation in HDV.<\/jats:p>","DOI":"10.1111\/jvh.13745","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T08:24:07Z","timestamp":1662366247000},"page":"1127-1133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Shear wave elastography: How well does it perform in chronic hepatitis D virus infection?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-5131","authenticated-orcid":false,"given":"Alexander H.","family":"Yang","sequence":"first","affiliation":[{"name":"Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health  Bethesda Maryland 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Radiology Clinical Center National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Marko","sequence":"additional","affiliation":[{"name":"Department of Radiology Clinical Center National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Heller","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4755-5607","authenticated-orcid":false,"given":"Christopher","family":"Koh","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch, National 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