{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:32Z","timestamp":1787015792477,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic hepatitis C virus (HCV) is common. Treatment with direct acting antivirals (DAA) result in high sustained virologic response (SVR) associated with normalization of alanine aminotransferase (ALT). However, abnormal ALT after SVR has been observed. Since fatty liver disease can co\u2010exist with HCV, its impact on abnormal ALT after SVR is unknown. This was a retrospective case\u2013control analysis evaluating those with SVR and baseline fatty liver disease by transient elastography defined by controlled attenuated parameter (CAP) was performed. Abnormal ALT was defined as &gt;1.5 ULN. The primary analysis compared abnormal ALT at SVR\u201012 and beyond in those with and without fatty liver disease. Six\u2010hundred and ninety\u2010three patients with SVR\u201012 were evaluated. Abnormal ALT at SVR\u201012 was present in 8.2% and was similar in those with and without fatty liver disease. Abnormal ALT at SVR\u201012 was associated with atrial fibrillation (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.02), CAP (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.047), age (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.08), baseline ALT (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.008), BMI (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.002) and obesity (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.02). On multivariate analysis, only BMI was associated with abnormal ALT at SVR\u201012 (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.017). ALT at follow\u2010up after SVR\u201012 was available in 264 patients. In those with initial normal ALT (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u2009244), 11.5% had a delayed abnormal ALT and in those with initial abnormal ALT (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200920), 47% remained abnormal while 53% normalized. Abnormal ALT after SVR following treatment with DAA is uncommon and related to increased BMI, but not related to underlying fatty liver disease assessed by CAP. The pattern of ALT can vary, and long\u2010term follow\u2010up is needed to assess the clinical impact of abnormal ALT after SVR.\n                  <\/jats:p>","DOI":"10.1111\/jvh.13763","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T09:38:32Z","timestamp":1666863512000},"page":"73-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence and predictors of abnormal alanine aminotransferase in patients with\n                    <scp>HCV<\/scp>\n                    who have achieved\n                    <scp>SVR<\/scp>"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7226-7343","authenticated-orcid":false,"given":"Nikita","family":"Chadha","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Virginia Commonwealth University Health System  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Virginia Commonwealth University Health System  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Sterling","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Virginia Commonwealth University Health System  Richmond Virginia USA"},{"name":"Department of Gastroenterology, Hepatology and Nutrition Virginia Commonwealth University Health System  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00472-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i4.1421"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305771"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0381-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S172512"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2013.09.007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50161"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.20294"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1121-421X.17.02467-9"},{"key":"e_1_2_9_11_1","unstructured":"American Association for the Study of Liver Diseases.Hepatitis C guidance 2019 update: American Association for the Study of Liver Diseases\u2013Infectious Diseases Society of America recommendations for testing managing and treating hepatitis C virus infection;2020.10.1002\/hep.31060#"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12883"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000000517"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07640.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/952684"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2017.08.010"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-1-200207020-00006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.12.022"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30357-5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i18.2793"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2029349"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078345818762591"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0685-x"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvh.13763","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T14:28:38Z","timestamp":1692455318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/jvh.13763"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13763","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,2]]},"assertion":[{"value":"2022-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}