{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:14:27Z","timestamp":1788455667659,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HBeAg seroconversion is an important treatment endpoint. We aimed to identify predictors of seroconversion using serum HBsAg and hepatitis B core\u2010related antigen (HBcrAg) in HBeAg\u2010positive patients treated with nucleos(t)ide analogs (NAs). Data and samples from 70 HBeAg\u2010positive patients treated with entecavir or tenofovir between January 2007 and December 2017 were retrospectively analysed. The mean follow\u2010up period was 11\u2009years. The predictive power for HBeAg seroconversion of HBcrAg levels at baseline and 2\u2009years after antiviral therapy was determined using receiver operating curve analysis. Twenty\u2010one patients (30%) achieved HBeAg seroconversion at a mean of 28 (range, 12\u201384) months after antiviral treatment. The median baseline HBcrAg and HBsAg levels were 6.9(5.7\u20137.0) vs. 5.8(5.5\u20136.5) log<jats:sub>10<\/jats:sub>U\/mL (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.006), 4.9(4.5\u20135.1) vs. 4.5(4.1\u20135.0) log<jats:sub>10<\/jats:sub>IU\/mL (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.044) in the no seroconversion group and seroconversion group, respectively. In the multivariate analysis, the serum HBcrAg levels at baseline and 2\u2009years after antiviral therapy were predictive factors for HBeAg seroconversion ([HR]; 0.326; [CI], 0.111\u20130.958; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.042 and HR, 0.4555; CI, 0.211\u20130.984; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.045). HBcrAg levels\u22646.5log<jats:sub>10<\/jats:sub>U\/mL at baseline and\u2009\u22645.3log<jats:sub>10<\/jats:sub>U\/mL at 2\u2009years after antiviral therapy had sensitivities of 53.1% and 69.8%, specificities of 95.2% and 70.6%, positive predictive values of 82.6% and 50.0%, and negative predictive values of 82.6% and 84.5%, respectively, with AUROCs of 0.712 (95%CI, 0.596\u20130.830) and 0.745 (95%CI, 0.599\u20130.891) for predicting HBeAg seroconversion. In chronic hepatitis B patients treated with NAs, HBcrAg levels\u22646.5log<jats:sub>10<\/jats:sub>U\/mL at baseline and\u2009\u22645.3log<jats:sub>10<\/jats:sub>U\/mL at 2\u2009years after antiviral therapy were useful predictive factors of HBeAg seroconversion.<\/jats:p>","DOI":"10.1111\/jvh.13765","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T14:32:15Z","timestamp":1667399535000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Baseline and on\u2010treatment <scp>HBcrAg<\/scp> levels as predictors of <scp>HBeAg<\/scp> seroconversion in chronic hepatitis B patients treated with antivirals"],"prefix":"10.1111","volume":"30","author":[{"given":"Soo Young","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine, Gangnam Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hwan","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine, Gangnam Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Young","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine, Gangnam Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sora","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine, Gangnam Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Il","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine, Gangnam Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan Sik","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine, Gangnam Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Youn","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Hyung","family":"Joon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Woong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine, Gangnam Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i20.6262"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309809"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60220-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.01.006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-009-9140-3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.12.042"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.1.65"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013215"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36026"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199605303342202"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14376"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13097"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2019.1002"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3350\/kjhep.2009.15.2.140"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2005.20.5.816"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.042"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169444"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.01.026"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00094.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2016.08.13"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10050357"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21339"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.11.030"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13346"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00111-0"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2016.0069"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2017.03.001"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840400407"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-016-9745-2"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.033324"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.11.039"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-12-183"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12889"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvh.13765","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T18:28:53Z","timestamp":1692469733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,11]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/jvh.13765"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13765","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,11]]},"assertion":[{"value":"2022-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}