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However, the impact of these two antiviral agents on the outcome of HBV\u2010related hepatocellular carcinoma (HCC) after curative therapy remains to be explored. The purpose of the present study was to compare the effect of ETV and TDF on recurrence and mortality after curative treatment for HBV\u2010related HCC. A comprehensive literature search of multiple electronic databases was conducted from 2000 to January 2022 for studies comparing ETV and TDF for HBV\u2010related HCC patients after curative therapy. The adjusted hazard ratios (aHR) were pooled using a random\u2010effects model. A total of nine studies with 5298 patients were included in the final meta\u2010analysis. TDF was associated with a lower risk of HCC recurrence [aHR 0.73, 95% confidence interval (CI) 0.65\u20130.81] compared to HCC. TDF reduced the risk of late recurrence compared to ETV (aHR 0.58, 95% CI 0.45\u20130.76) but not early recurrence (aHR 0.88, 95% CI 0.76\u20131.02). The mortality risk was also lower with TDF compared to ETV (aHR 0.62, 95% CI 0.50\u20130.77). TDF was associated with a lower risk of recurrence and mortality than ETV after resection or ablation of HBV\u2010related HCC. Further prospective randomized controlled studies are warranted to validate these results.<\/jats:p>","DOI":"10.1111\/jvh.13766","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T14:41:58Z","timestamp":1667400118000},"page":"108-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Tenofovir versus entecavir for tertiary prevention of hepatocellular carcinoma in chronic hepatitis B infection after curative therapy: A systematic review and <scp>meta\u2010analysis<\/scp>"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9626-5243","authenticated-orcid":false,"given":"Suprabhat","family":"Giri","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Nizam's Institute of Medical Sciences  Hyderabad 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