{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:03:22Z","timestamp":1785168202890,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the short\u2010term and long\u2010term survival efficacy of an artificial liver support system (ALSS) in patients with acute\u2010on\u2010chronic liver failure (ACLF). A systematic search was performed for relevant published data in PubMed, Web of Science and Cochrane Library databases. Studies that evaluated the efficacy of ALSS in patients with ACLF and provided the short\u2010term or long\u2010term survival rate were included. A total of 10 studies involving 3685 patients were included in this analysis. The pooled 28\u2010day survival rate and 90\u2010day survival rate were 68.7% (95% CI: 64.5%\u201372.9%) and 53.4% (95% CI: 45.5%\u201361.4%), respectively. The pooled estimates of the OR for the 28\u2010day and 90\u2010day survival rates between the ALSS group and the control group were 1.91 (95% CI: 1.21\u20133.04) and 1.41 (95% CI: 1.17\u20131.70), respectively. Subgroup analysis showed that patients treated with lower levels of TBIL and MELD scores had a higher 28\u2010day survival rate (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a015.75, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a013.80, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The present meta\u2010analysis suggests that ALSS treatment could remarkably improve short\u2010term survival rates in HBV\u2010ACLF patients, which implies that treatment with ALSS may help to reduce high mortality. Further prospective randomized trials are needed to validate these findings.<\/jats:p>","DOI":"10.1111\/jvh.13767","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T17:39:56Z","timestamp":1667497196000},"page":"90-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Artificial liver support systems for hepatitis B virus\u2010associated acute\u2010on\u2010chronic liver failure: A meta\u2010analysis of the clinical literature"],"prefix":"10.1111","volume":"30","author":[{"given":"Guotao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Luoyang Central Hospital Affiliated to Zhengzhou University  Luoyang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Luoyang Central Hospital Affiliated to Zhengzhou University  Luoyang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Luoyang Central Hospital Affiliated to Zhengzhou University  Luoyang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312670"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2018.1426459"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32789"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314641"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25781"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2006.00358.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-018-0453-z"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i2.219"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2011.624102"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.056"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002506"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284819879565"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13497"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3757149"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14328"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.07.007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21762"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21535"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21690"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1499-3872(16)60084-x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175332"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000338"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53029-0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1021986624600"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i32.9614"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130197"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002361"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i10.1184"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9667-4"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i40.7303"}],"container-title":["Journal 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