{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:01:44Z","timestamp":1792839704292,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Direct\u2010acting antiviral drugs (DAA) are safe and effective in the HCV population. However, in patients with decompensated cirrhosis and\/or active hepatocellular carcinoma or relapse to NS5A inhibitors, response rates are lower and DAA therapy must be postponed until after liver transplant in an era of organ shortage and suboptimal donors. We aimed to assess the prevalence of patients still HCV infected at time of transplantation over the last 3\u2009years in our Center and describe the safety and efficacy of DAA therapy started as soon as possible after surgery. We enrolled all HCV viraemic patients transplanted in our Centre from January 2019 to March 2022. The follow\u2010up was closed in July 2022. Among 490 liver transplants, 49 (10%) patients were still HCV viraemic at operation, 43 naive to DAA and 6 were NS5A\u2010experienced. Median donor age was 64\u2009years; donor risk index was 1.8. In naive patients, sofosbuvir\/velpatasvir was started after a median time of 1\u2009day from surgery, while in NS5A\u2010experienced sofosbuvir\/velpatasvir\/voxilaprevir after 14.5\u2009days (<jats:italic>p<\/jats:italic>\u00a0=\u2009.001). Response rate was 98%. 1 NS5A\u2010experienced patient experienced acute cholestatic hepatitis which promptly reverted after permanent DAA discontinuation. Hence, very early post\u2010liver transplant HCV eradication was safe and effective thanks to a close teamwork which involved anaesthesiologists, transplant surgeons and hepatologists.<\/jats:p>","DOI":"10.1111\/jvh.13782","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T20:39:23Z","timestamp":1670445563000},"page":"201-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early post\u2010liver transplant use of direct\u2010acting antivirals in naive and <scp>NS5A<\/scp> inhibitor\u2010experienced <scp>HCV<\/scp> patients"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0838-9060","authenticated-orcid":false,"given":"Margherita","family":"Saracco","sequence":"first","affiliation":[{"name":"Gastrohepatology Unit Azienda Ospedaliero\u2010Universitaria Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3166-6684","authenticated-orcid":false,"given":"Francesco","family":"Tandoi","sequence":"additional","affiliation":[{"name":"Liver Transplantation Center and General Surgery 2U Azienda Ospedaliero\u2010Universitaria Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7877-030X","authenticated-orcid":false,"given":"Francesca","family":"Maletta","sequence":"additional","affiliation":[{"name":"Pathology Unit Azienda Ospedaliero\u2010Universitaria Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Balagna","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit 2 Azienda Ospedaliero\u2010Universitaria Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8340-8885","authenticated-orcid":false,"given":"Renato","family":"Romagnoli","sequence":"additional","affiliation":[{"name":"Liver Transplantation Center and General Surgery 2U Azienda Ospedaliero\u2010Universitaria Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9738-5538","authenticated-orcid":false,"given":"Silvia","family":"Martini","sequence":"additional","affiliation":[{"name":"Gastrohepatology Unit Azienda Ospedaliero\u2010Universitaria Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.01.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001591"},{"key":"e_1_2_9_4_1","unstructured":"World Health Organization.Hepatitis C.2021.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/hepatitis\u2010c"},{"key":"e_1_2_9_5_1","unstructured":"World Health Organization.Global health sector strategy on viral hepatitis 2016\u201320212016.http:\/\/apps.who.int\/iris\/bitstream\/10665\/246177\/1\/WHO\u2010HIV\u20102016.06\u2010eng.pdf"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.07.042"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512610"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512610"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.592472"},{"key":"e_1_2_9_10_1","first-page":"710","article-title":"Front efficacy and safety of direct\u2010acting antiviral therapy in patients with chronic hepatitis C virus infection: a real\u2010world single\u2010center experience in Tianjin, China","volume":"11","author":"Xia H","year":"2020","journal-title":"Pharmacol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001708"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.031"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.02.027"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.01.020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31060"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.08.018"},{"key":"e_1_2_9_17_1","unstructured":"FDA.FDA warns about rare occurrence of serious liver injury with use of hepatitis C medicines Mavyret Zepatier and Vosevi in some patients with advanced liver disease.https:\/\/www.fda.gov\/drugs\/drug\u2010safety\u2010and\u2010availability\/fda\u2010warns\u2010about\u2010rare\u2010occurrence\u2010serious\u2010liver\u2010injury\u2010use\u2010hepatitis\u2010c\u2010medicines\u2010mavyret\u2010zepatier\u2010and"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1611829"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30046"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.039"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005070"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v12.i12.1341"},{"key":"e_1_2_9_23_1","unstructured":"FDA.Resoconto CRT Centro Regionale Trapianti Anno.2020.https:\/\/www.trapiantipiemonte.it\/wp\u2010content\/uploads\/2021\/12\/ReportCRT2020.pdf page 14."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.12.009"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24772"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22091"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_9_28_1","unstructured":"FDA.Sofosbuvir\/velpatasvir (Epclusa) summary of product characteristics.https:\/\/www.ema.europa.eu\/en\/documents\/product\u2010information\/epclusa\u2010epar\u2010product\u2010information_en.pdf"},{"key":"e_1_2_9_29_1","unstructured":"FDA.Serious adverse reaction definition.https:\/\/www.ema.europa.eu\/en\/glossary\/serious\u2010adverse\u2010reaction"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24072"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.07.002"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1280"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2020.00062"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.07.020"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02107-1"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvh.13782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T23:09:04Z","timestamp":1692313744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,16]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/jvh.13782"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13782","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,16]]},"assertion":[{"value":"2022-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}