{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:11:12Z","timestamp":1782587472729,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Noninvasive methods for assessing hepatic fibrosis are clinically necessary. This study aims to explore HBV markers correlated with liver fibrosis and capable of diagnosing significant fibrosis and predicting fibrosis regression. Seventy\u2010four HBeAg\u2010positive chronic hepatitis B (CHB) patients were enrolled and started on entecavir or adefovir therapy. Serum HBV RNA, HBV DNA, HBsAg and hepatitis B core\u2010related antigen (HBcrAg) levels were measured at baseline and during treatment. Liver fibrosis was assessed at baseline and month 60 by liver biopsy. Fibrosis regression was defined as Ishak fibrosis score decreased \u22651\u2010point. At baseline, HBsAg, HBcrAg and HBV RNA levels had a stronger correlation with Ishak fibrosis score (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.441, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002; <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.469, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001; <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.398, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) than APRI and FIB\u20104 (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.321 <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006; <jats:italic>r<\/jats:italic>\u00a0=\u00a0.371, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). HBsAg &gt;4 log<jats:sub>10<\/jats:sub> IU\/ml plus HBcrAg &gt;7 log<jats:sub>10<\/jats:sub> IU\/ml or HBsAg &gt;4 log<jats:sub>10<\/jats:sub> IU\/ml plus HBV RNA\u2009&gt;5 log<jats:sub>10<\/jats:sub> copies\/ml exhibited the same excellent diagnostic ability for significant fibrosis with the AUROC of 0.857. After 60\u2009months of antiviral treatment, 66.7% of patients who suffered significant fibrosis at baseline achieved fibrosis regression, and an HBV RNA decline from baseline to month 6 greater than 0.63 log<jats:sub>10<\/jats:sub> copies\/ml could predict the fibrosis regression at month 60. In conclusion<jats:italic>,<\/jats:italic> serum HBsAg, HBcrAg and HBV RNA are potential markers for predicting significant liver fibrosis. HBV RNA measurement would be particularly useful for monitoring hepatic fibrosis changes in HBeAg\u2010positive CHB patients.<\/jats:p>","DOI":"10.1111\/jvh.13790","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T10:10:18Z","timestamp":1671444618000},"page":"303-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum <scp>HBV RNA<\/scp> is associated with liver fibrosis regression in <scp>HBeAg<\/scp>\u2010positive chronic hepatitis B patients treated with nucleos(t)ide analogues"],"prefix":"10.1111","volume":"30","author":[{"given":"Dandan","family":"Bian","sequence":"first","affiliation":[{"name":"Liver Disease Center, Beijing YouAn Hospital Capital Medical University  Beijing China"},{"name":"Department of Infectious Diseases, Electric Power Teaching Hospital Capital Medical University  Beijing 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