{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T16:27:39Z","timestamp":1777825659793,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011893","name":"Pan American Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011893","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In July 2020, the Mexican Government initiated the National Program for Elimination of Hepatitis C (HCV) under a procurement agreement, securing universal, free access to HCV screening, diagnosis and treatment for 2020\u20132022. This analysis quantifies the clinical and economic burden of HCV (MXN) under a continuation (or end) to the agreement. A modelling and Delphi approach was used to evaluate the disease burden (2020\u20132030) and economic impact (2020\u20132035) of the Historical Base compared to Elimination, assuming the agreement continues (Elimination\u2014Agreement to 2035) or terminates (Elimination\u2014Agreement to 2022). We estimated cumulative costs and the per\u2010patient treatment expenditure needed to achieve net\u2010zero cost (the difference in cumulative costs between the scenario and the base). Elimination is defined as a 90% reduction in new infections, 90% diagnosis coverage, 80% treatment coverage and 65% reduction in mortality by 2030. A viraemic prevalence of 0.55% (0.50\u20130.60) was estimated on 1st January 2021, corresponding to 745,000 (95% CI 677,000\u2013812,000) viraemic infections in Mexico. The Elimination\u2014Agreement to 2035 would achieve net\u2010zero cost by 2023 and accrue 31.2 billion in cumulative costs. Cumulative costs under the Elimination\u2014Agreement to 2022 are estimated at 74.2 billion. Under Elimination\u2014Agreement to 2022, the per\u2010patient treatment price must decrease to 11,000 to achieve net\u2010zero cost by 2035. The Mexican Government could extend the agreement through 2035 or reduce the cost of HCV treatment to 11,000 to achieve HCV elimination at net\u2010zero cost.<\/jats:p>","DOI":"10.1111\/jvh.13828","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T05:53:32Z","timestamp":1678341212000},"page":"551-558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cost\u2010effectiveness and economic investment to eliminate chronic hepatitis C in Mexico"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2281-8105","authenticated-orcid":false,"given":"Ellen","family":"Mooneyhan","sequence":"first","affiliation":[{"name":"Center for Disease Analysis Foundation (CDAF)  Lafayette Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alethse","family":"De\u00a0la\u00a0Torre\u00a0Rosas","sequence":"additional","affiliation":[{"name":"National Center for the Prevention and Control of HIV (CENSIDA)  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Bernal","family":"Serrano","sequence":"additional","affiliation":[{"name":"National Center for the Prevention and Control of HIV (CENSIDA)  Mexico City Mexico"},{"name":"Instituto Tecnol\u00f3gico y de Estudios Superiores de Monterrey (ITESM)  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivane","family":"Gamkrelidze","sequence":"additional","affiliation":[{"name":"Center for Disease Analysis Foundation (CDAF)  Lafayette Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jesus","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Pan American Health Organization\/World Health Organization  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kershenobich","sequence":"additional","affiliation":[{"name":"The National Institute of Medical Sciences and Nutrition  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro","family":"Sereno","sequence":"additional","affiliation":[{"name":"Pan American Health Organization\/World Health Organization  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homie","family":"Razavi","sequence":"additional","affiliation":[{"name":"Center for Disease Analysis Foundation (CDAF)  Lafayette Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"35","article-title":"Report of a WHO Consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp","volume":"6","author":"Global Surveillance and Control of Hepatitis C","year":"1999","journal-title":"Belgium J Viral Hepat"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v6.i15.922"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2021.100151"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0145-y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rgmx.2014.09.004"},{"key":"e_1_2_11_7_1","first-page":"1","volume-title":"Mexico Programa de Accion Especifico Virus de Hepatitis C, 2020\u20102024: Ciudad de M\u00e9xico","author":"Secretar\u00eda de Salud","year":"2021"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13673"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30270-X"},{"key":"e_1_2_11_10_1","volume-title":"Global health sector strategy on viral hepatitis 2016\u20132021, Towards ending viral hepatitis","author":"World Health Organization","year":"2016"},{"key":"e_1_2_11_11_1","first-page":"1","article-title":"Eliminating hepatitis C in Mexico: A primary health care approach","volume":"0","author":"De la Torre Rosas A","year":"2021","journal-title":"Clin Liver Dis"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30181-9"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00472-6"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-36342007000900011"},{"key":"e_1_2_11_15_1","volume-title":"AAMATES 2020\u20102021 program data","author":"Ambiente de Administraci\u00f3n y Manejo de Atenciones en Salud (3)","year":"2021"},{"key":"e_1_2_11_16_1","volume-title":"Current Status of Transplants and Donations in Mexico","author":"National Transplant Center","year":"2013"},{"key":"e_1_2_11_17_1","volume-title":"Data on liver transplants due to HCV","author":"CENTERA","year":"2021"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.21149\/spm.v58i2.7780"},{"key":"e_1_2_11_19_1","unstructured":"Globocan Mexico Source 2020; 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