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Based on a systematic literature review, the reappraisal of a 2015 prevalence analysis assuming 0.5% prevalence among the Swiss population and data from many additional sources, we estimated the prevalence among subpopulations at increased risk and the general population. For new transmissions, we evaluated mandatory HCV notification data and estimated unreported new transmissions based on subpopulation characteristics. For the mortality estimate, we re\u2010evaluated a previous mortality estimate 1995\u20132014 based on new data on comorbidities and age. We found a prevalence of \u22640.1% among the Swiss population. Discrepancies to the 2015 estimate were explained by previous (i) underestimation of sustained virologic response numbers, (ii) overestimation of HCV prevalence among PWID following bias towards subgroups at highest risk, (iii) overestimation of HCV prevalence among the general population from inclusion of high\u2010risk persons and (iv) underestimation of spontaneous clearance and mortality. Our results suggest that the WHO elimination targets have been met 10\u2009years earlier than previously foreseen. These advancements were made possible by Switzerland's outstanding role in harm\u2010reduction programmes, the longstanding micro\u2010elimination efforts concerning HIV\u2010infected MSM and nosocomial transmissions, little immigration from high\u2010prevalence countries except Italian\u2010born persons born before 1953, and wealth of data and funding.<\/jats:p>","DOI":"10.1111\/jvh.13842","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T01:47:05Z","timestamp":1686188825000},"page":"667-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic hepatitis C virus infections in Switzerland in 2020: Lower than expected and suggesting achievement of <scp>WHO<\/scp> elimination targets"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-4245","authenticated-orcid":false,"given":"Barbara","family":"Bertisch","sequence":"first","affiliation":[{"name":"Checkin Zollhaus  Z\u00fcrich Switzerland"},{"name":"Institute of Global Health, University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schaetti","sequence":"additional","affiliation":[{"name":"Communicable Diseases Division, Federal Office of Public Health  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Schmid","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology Cantonal Hospital St. Gallen  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Peter","sequence":"additional","affiliation":[{"name":"Department of International Relations London School of Economics and Political Science  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Vernazza","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinic  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Isler","sequence":"additional","affiliation":[{"name":"Private Physician  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Oppliger","sequence":"additional","affiliation":[{"name":"Private Physician  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel Jeremias","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Communicable Diseases Division, Federal Office of Public Health  Bern Switzerland"},{"name":"Division of Infectious Diseases and Hospital Epidemiology Cantonal Hospital St. Gallen  St. Gallen Switzerland"},{"name":"Department of Public Health Environments and Society, London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"ZahndC BrezziM BertischB GiudiciF KeiserO.Analyse de situation des h\u00e9patitides B et C en Suisse. 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