{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:01:44Z","timestamp":1792839704309,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis C virus (HCV) infection is more prevalent in people living with HIV\u2010AIDS (PLHA) and portends a poorer prognosis. Pharmacokinetic studies suggest the absence of significant interaction between velpatasvir and dolutegravir which has been recently recommended as part of preferred first\u2010line antiretroviral therapy (ART) regimens by WHO. However, clinical data on the use of velpatasvir\u2010based regimen in PLHA taking dolutegavir is lacking. Hence, we aimed to assess the efficacy and safety of sofosbuvir and velpatasvir (SOF\u2009+\u2009VEL) in HCV and HIV coinfected patients on dolutegravir\u2010based ART. Forty\u2010five consecutive PLHA with HCV coinfection on dolutegravir\u2010based ART were prospectively enrolled. All patients were treated SOF\u2009+\u2009VEL for 12\u2009weeks. Complete haemogram, liver and renal function tests were assessed at baseline, 4\u2009weeks and at end of treatment. Sustained virological response (SVR) was assessed at 12\u2009weeks after end of treatment. The majority were males (95.5%) with a mean age of 32.8\u2009\u00b1\u200912.3\u2009years. Cirrhosis was present in 6 (13.3%) patients. All patients completed 12\u2009weeks of therapy with SOF\u2009+\u2009VEL, but SVR could not be assessed in two patients. Forty\u2010two (97.7%) of the remaining 43 patients attained SVR\u201012. SVR\u201012 rate was 97.7% and 93.3% by per protocol and intention to treat analysis, respectively. No grade III\/IV adverse events were reported, and there was no worsening of blood counts, liver or renal function test parameters. The pan\u2010genotypic regimen of SOF\u2009+\u2009VEL is safe and effective in PLHA with HCV coinfection who are on dolutegravir\u2010based ART.<\/jats:p>","DOI":"10.1111\/jvh.13844","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T11:29:10Z","timestamp":1685618950000},"page":"740-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and safety of pan\u2010genotypic sofosbuvir and velpatasvir in patients with hepatitis C and <scp>HIV<\/scp> coinfection on\u00a0dolutegravir\u2010based antiretroviral therapy"],"prefix":"10.1111","volume":"30","author":[{"given":"Arka","family":"De","sequence":"first","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Charak","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Bhagat","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahaj","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipun","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-4148","authenticated-orcid":false,"given":"Madhumita","family":"Premkumar","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Taneja","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapil","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and School of Public Health Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9113-5167","authenticated-orcid":false,"given":"Virendra","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-2664","authenticated-orcid":false,"given":"Ajay","family":"Duseja","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31311-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60604-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1112"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00485-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.29201"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-9-201305070-00604"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-1829"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12204"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62001-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy585"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.08.018"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.1137"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-019-00774-0"},{"key":"e_1_2_11_15_1","volume-title":"Update of recommendations on first\u2010 and second\u2010line antiretroviral regimens","year":"2019"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy201"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix260"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.02.002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.018"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.996"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/321909"},{"key":"e_1_2_11_23_1","volume-title":"National Guidelines for Diagnosis & Management of Viral Hepatitis","year":"2018"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5916.92626"},{"key":"e_1_2_11_25_1","unstructured":"National AIDS Control Organization.National Guidelines for HIV Care and Treatment 2021. New Delhi: NACO Ministry of Health and Family Welfare Government of India.2021."},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14537"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512612"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512610"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073613"},{"key":"e_1_2_11_30_1","first-page":"950","article-title":"Hepatitis B and\/or C co\u2010infection in HIV infected patients: A study in a tertiary care centre from south India","volume":"138","author":"Chandra N","year":"2013","journal-title":"Indian J Med Res"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5916.182626"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181831e85"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:02:34Z","timestamp":1692565354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/jvh.13844"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13844","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2023-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}