{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T04:42:32Z","timestamp":1692333752363},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014386","name":"Abbott Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NCT01924455","NCT01263587","K24AA022523"],"award-info":[{"award-number":["NCT01924455","NCT01263587","K24AA022523"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis B virus (HBV) RNA and hepatitis B core\u2010related antigen (HBcrAg), reflecting transcriptional activity of covalently closed circular DNA, are gaining traction as important markers to assess viral activity. Whether their expression differs under viral suppression by HIV co\u2010infection status is unknown. Among adults with chronic HBV on antiviral therapy, we sought to determine if the expression of HBV markers (specialized and well\u2010established) differs between HBV\u2010HIV co\u2010infection vs. HBV mono\u2010infection. We compared HBV marker levels among 105 participants in the Hepatitis B Research Network (HBRN) HBV\u2010HIV Ancillary Study and 105 participants in the HBRN mono\u2010infected Cohort Study, matched for HBeAg status and HBV DNA suppression on therapy. Among HBeAg+ participants (<jats:italic>N<\/jats:italic>\u2009=\u200958 per group), after adjusting for age, sex, race, ALT and HBV DNA, viral markers were higher (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) in the HBV\u2010HIV versus the HBV\u2010only sample (HBeAg: 1.05 vs. 0.51 log<jats:sub>10<\/jats:sub> IU\/mL; HBsAg: 3.85 vs. 3.17 log<jats:sub>10<\/jats:sub> IU\/mL; HBV RNA: 5.60 vs. 3.70 log<jats:sub>10<\/jats:sub> U\/mL; HBcrAg: 6.59 vs. 5.51 log<jats:sub>10<\/jats:sub> U\/mL). Conversely, among HBeAg(\u2212) participants (<jats:italic>N<\/jats:italic>\u2009=\u200947 per group), HBsAg (2.00 vs. 3.04 log10 IU\/mL) and HBV RNA (1.87 vs. 2.66 log<jats:sub>10<\/jats:sub> U\/mL) were lower (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) in HBV\u2010HIV vs. HBV\u2010only; HBcrAg levels were similar (4.14 vs. 3.64 log<jats:sub>10<\/jats:sub> U\/mL; <jats:italic>p<\/jats:italic>\u2009=\u2009.27). Among adults with chronic HBV with suppressed viremia on antiviral therapy, viral markers tracked with HIV co\u2010infection status and associations differed inversely by HBeAg status. The greater sensitivity and specificity of HBV RNA compared to HBcrAg allows for better discrimination of transcriptional activity regardless of HBeAg status.<\/jats:p>","DOI":"10.1111\/jvh.13857","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T11:02:56Z","timestamp":1686135776000},"page":"700-709","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human immunodeficiency virus coinfection differentially impacts hepatitis B virus viral markers based on hepatitis Be antigen status in patients with suppressed viremia"],"prefix":"10.1111","volume":"30","author":[{"given":"Mauricio","family":"Lisker\u2010Melman","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine and John Cochran VA Medical Center  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy C.","family":"King","sequence":"additional","affiliation":[{"name":"School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc G.","family":"Ghany","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch NIDDK, NIH  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond T.","family":"Chung","sequence":"additional","affiliation":[{"name":"Liver Center Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda S.","family":"Hinerman","sequence":"additional","affiliation":[{"name":"Epidemiology Department, School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin A.","family":"Cloherty","sequence":"additional","affiliation":[{"name":"Abbott Diagnostics  Lake Forest Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandana","family":"Khalili","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California at San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamta K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine UT Southwestern Medical Center &amp; Parkland Health &amp; Hospital System  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Sulkowski","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard K.","family":"Sterling","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0737-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036349"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27381"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.029"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1259-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24657"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.436"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.12.038"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.06.028"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0409-9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-1-200207020-00006"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30082"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32018"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32634"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T07:35:19Z","timestamp":1692257719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/jvh.13857"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13857","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,6]]},"assertion":[{"value":"2023-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}