{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:11:45Z","timestamp":1768993905025,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The World Health Organization (WHO) aims to reduce HCV mortality, but estimates are difficult to obtain. We aimed to identify electronic health records of individuals with HCV infection, and assess mortality and morbidity. We applied electronic phenotyping strategies on routinely collected data from patients hospitalized at a tertiary referral hospital in Switzerland between 2009 and 2017. Individuals with HCV infection were identified using International Classification of Disease (ICD)\u201010 codes, prescribed medications and laboratory results (antibody, PCR, antigen or genotype test). Controls were selected using propensity score methods (matching by age, sex, intravenous drug use, alcohol abuse and HIV co\u2010infection). Main outcomes were in\u2010hospital mortality and attributable mortality (in HCV cases and study population). The non\u2010matched dataset included records from 165,972 individuals (287,255 hospital stays). Electronic phenotyping identified 2285 stays with evidence of HCV infection (1677 individuals). Propensity score matching yielded 6855 stays (2285 with HCV, 4570 controls). In\u2010hospital mortality was higher in HCV cases (RR 2.10, 95%CI 1.64 to 2.70). Among those infected, 52.5% of the deaths were attributable to HCV (95%CI 38.9 to 63.1). When cases were matched, the fraction of deaths attributable to HCV was 26.9% (HCV prevalence: 33%), whilst in the non\u2010matched dataset, it was 0.92% (HCV prevalence: 0.8%). In this study, HCV infection was strongly associated with increased mortality. Our methodology may be used to monitor the efforts towards meeting the WHO elimination targets and underline the importance of electronic cohorts as a basis for national longitudinal surveillance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jvh.13861","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T06:57:37Z","timestamp":1686639457000},"page":"765-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mortality and morbidity related to hepatitis C virus infection in hospitalized adults\u2014A propensity score matched analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4181-2948","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9rique","family":"Hovaguimian","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital of Zurich, University of Zurich  Zurich Switzerland"},{"name":"Department of Public and Global Health, Epidemiology, Biostatistics and Prevention Institute University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick E.","family":"Beeler","sequence":"additional","affiliation":[{"name":"Division of Occupational and Environmental Medicine, Epidemiology, Biostatistics and Prevention Institute University of Zurich and University Hospital Zurich  Zurich Switzerland"},{"name":"Center for Primary and Community Care University of Lucerne  Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"M\u00fcllhaupt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huldrych F.","family":"G\u00fcnthard","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital of Zurich, University of Zurich  Zurich Switzerland"},{"name":"Institute of Medical Virology, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Maeschli","sequence":"additional","affiliation":[{"name":"Swiss Hepatitis  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Bruggmann","sequence":"additional","affiliation":[{"name":"Swiss Hepatitis  Zurich Switzerland"},{"name":"Arud Centre for Addiction Medicine  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan S.","family":"Fehr","sequence":"additional","affiliation":[{"name":"Department of Public and Global Health, Epidemiology, Biostatistics and Prevention Institute University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger D.","family":"Kouyos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital of Zurich, University of Zurich  Zurich Switzerland"},{"name":"Institute of Medical Virology, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Global Hepatitis Report 2017","author":"World Health Organization","year":"2017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4284-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30303-4"},{"key":"e_1_2_10_5_1","volume-title":"Global Health Sector Strategy on Viral Hepatitis 2016\u20132021. 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Treatment of Chronic Hepatitis C\u2014September 2015 Update 2015."}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:03:02Z","timestamp":1692565382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,12]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/jvh.13861"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13861","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,12]]},"assertion":[{"value":"2023-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}