{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:02:05Z","timestamp":1792587725679,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease. The association between prior hepatitis B virus (HBV), hepatitis A virus (HAV), hepatitis E virus (HEV) infection and NAFLD remains unclear. We utilized the 2017\u20132020 National Health and Nutrition Examination Survey (NHANES) and performed multivariable logistic regression analyses to examine the association of prior HBV, HAV and HEV infection with NAFLD, as well as high risk non\u2010alcoholic steatohepatitis (NASH) and liver fibrosis. Our analysis included 2565 participants with available anti\u2010HBc serology results, 1480 unvaccinated participants with anti\u2010HAV results, and 2561 participants with anti\u2010HEV results. Among participants with NAFLD, the age\u2010adjusted prevalence of prior HBV, HAV and HEV infection was 3.48%, 32.08% and 7.45%, respectively. Prior infection with HBV, HAV and HEV was not associated with NAFLD (cut\u2010off 285\u2009dB\/m) [aOR: 0.99 (95% CI, 0.77\u20131.29), 1.29 (95% CI, 0.95\u20131.75), and 0.94 (95% CI, 0.70\u20131.27), respectively] or high\u2010risk NASH [aOR 0.72 (95% CI, 0.45\u20131.17), 0.92 (95% CI, 0.55\u20131.52), and 0.89 (95% CI, 0.41\u20131.94), respectively]. Participants with anti\u2010HBc and anti\u2010HAV seropositivity were more likely to have significant fibrosis [aOR: 1.53 (95% CI, 1.05\u20132.23) and 1.69 (95% CI, 1.16\u20132.47), respectively]. The odds of significant fibrosis are 53%, and 69% greater for participants with prior history of HBV and HAV infection. Healthcare providers should prioritize vaccination efforts and employ a tailored approach to NAFLD in patients with prior viral hepatitis and especially HBV or HAV infection to limit disease\u2010related outcomes.<\/jats:p>","DOI":"10.1111\/jvh.13862","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T06:56:16Z","timestamp":1686639376000},"page":"685-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of prior HBV, HAV, and HEV infection on non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Stephanos","family":"Vassilopoulos","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Warren Alpert Medical School of Brown University, Rhode Island Hospital  Rhode Island 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