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However, no studies have evaluated the prevalence or determinants of HDV infection among people with HIV\/HBV in the US. We performed a cross\u2010sectional study among adults with HIV\/HBV coinfection receiving care at eight sites within the Center for AIDS Research Network of Integrated Clinical Systems (CNICS) between 1996 and 2019. Among patients with available serum\/plasma specimens, we selected the first specimen on or after their initial HBV qualifying test. All samples were tested for HDV IgG antibody and HDV RNA. Multivariable log\u2010binomial generalized linear models were used to estimate prevalence ratios (PRs) with 95% CIs of HDV IgG antibody\u2010positivity associated with determinants of interest (age, injection drug use [IDU], high\u2010risk sexual behaviour). Among 597 adults with HIV\/HBV coinfection in CNICS and available serum\/plasma samples (median age, 43\u2009years; 89.9% male; 52.8% Black; 42.4% White), 24\/597 (4.0%; 95% CI, 2.4%\u20135.6%) were HDV IgG antibody\u2010positive, and 10\/596 (1.7%; 95% CI, 0.6%\u20132.7%) had detectable HDV RNA. In multivariable analysis, IDU was associated with exposure to HDV infection (adjusted PR\u2009=\u20092.50; 95% CI, 1.09\u20135.74). In conclusion, among a sample of adults with HIV\/HBV coinfection in care in the US, 4.0% were HDV IgG antibody\u2010positive, among whom 41.7% had detectable HDV RNA. History of IDU was associated with exposure to HDV infection. These findings emphasize the importance of HDV testing among persons with HIV\/HBV coinfection, especially those with a history of IDU.<\/jats:p>","DOI":"10.1111\/jvh.13874","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T05:00:25Z","timestamp":1690261225000},"page":"879-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence and determinants of hepatitis delta virus infection among <scp>HIV<\/scp>\/hepatitis <scp>B\u2010coinfected<\/scp> adults in care in the United States"],"prefix":"10.1111","volume":"30","author":[{"given":"Nicole D.","family":"Ferrante","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Kallan","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Sukkestad","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Kodani","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari M.","family":"Kitahata","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Disease University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"Cachay","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases and Global Public Health University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debika","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya","family":"Heath","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Disease University of Alabama  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Napravnik","sequence":"additional","affiliation":[{"name":"Department of Medicine University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8474-1812","authenticated-orcid":false,"given":"George","family":"Yendewa","sequence":"additional","affiliation":[{"name":"Department of Medicine Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth H.","family":"Mayer","sequence":"additional","affiliation":[{"name":"The Fenway Institute, Fenway Health  Boston Massachusetts USA"},{"name":"Department of Medicine Beth Israel Deaconess Medical Center\/Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Rajender","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya","family":"Hayden","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleem","family":"Kamili","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey N.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6710-9666","authenticated-orcid":false,"given":"H. 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