{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:33:48Z","timestamp":1794004428352,"version":"4.8.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hepatitis C virus infection (HCV) is prevalent in prisons. Therefore, effective prison HCV services are critical for HCV elimination programmes. We aimed to evaluate the efficacy of a regional HCV prison testing and treatment programme. Between July 2017 and June 2022, data were collected prospectively on HCV test offer and uptake rates, HCV Antibody (HCV\u2010Ab) and HCV\u2010RNA positivity, treatment starts and outcomes for new inmates incarcerated in three prisons. Rates of HCV\u2010Ab and RNA positivity at reception, incidence of new HCV infections and reinfection following treatment were determined. From a total of 39,652 receptions, 33,028 (83.3%) were offered HCV testing and 20,394 (61.7%) completed testing. Including all receptions, 24.5% of tests (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094995) were HCV\u2010Ab positive and 8.4% of tests (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091713) were HCV\u2010RNA positive. When considering the first test for each individual (median age 34\u2009years; 88.1% male), 14.8% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091869) and 7.2% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009905) were HCV\u2010Ab and HCV\u2010RNA positive, respectively. The incidence of new HCV\u2010Ab and RNA positivity was 5.1 and 3.3 per 100 person\u2010years, respectively. Of 1145 HCV viraemic individuals, 18 died within 6\u2009months and 150 were rapidly transferred out of area, leaving 977 individuals with outcomes. Of these, 835 (85.5%) received antivirals and 47 spontaneously cleared the infection, leaving 95 (9.7%) untreated. 607 (72.7%) achieved SVR. 95 patients had reinfection post\u2010treatment (rate 10.1 cases per 100 person\u2010years). Testing for HCV has increased in our prisons and the majority with viraemia are initiated on antiviral treatment. Reassuringly, a significant fall in frequency of HCV\u2010RNA positivity at prison reception was observed suggesting progress towards HCV elimination.\n                  <\/jats:p>","DOI":"10.1111\/jvh.13887","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:55:43Z","timestamp":1694566543000},"page":"914-921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Impact of 5\u2009years of hepatitis C testing and treatment in the North East of England prisons"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-4413","authenticated-orcid":false,"given":"Amy","family":"Johnson","sequence":"first","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne 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Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Kerry","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dee","family":"Jones","sequence":"additional","affiliation":[{"name":"Spectrum Community Health  Wakefield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"McCullough","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Miller","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Valappil","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Virology Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusri","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Virology Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1041-9844","authenticated-orcid":false,"given":"Steven","family":"Masson","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"},{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Jefferson","sequence":"additional","affiliation":[{"name":"Hepatitis C Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Lawton","sequence":"additional","affiliation":[{"name":"Hepatitis C Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Christensen","sequence":"additional","affiliation":[{"name":"Hepatitis C Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-2453","authenticated-orcid":false,"given":"Stuart","family":"McPherson","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"},{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne 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