{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:16:26Z","timestamp":1785860186749,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic hepatitis B (CHB) infection has far\u2010reaching implications for patients' quality of life (QOL), regardless of cirrhosis or complications. However, limited research exists on the psychosocial impact of CHB, particularly in asymptomatic, noncirrhotic patients. Noncirrhotic CHB patients without comorbidities affecting QOL were evaluated in hepatology clinics. Patients underwent a standardized interview and completed the Short Form\u201012 (SF\u201012) questionnaire. Multiple social and psychological parameters were compared between patients receiving chronic treatment and untreated controls with HBeAg\u2010negative chronic infections. A total of 41 CHB patients were included in the study, with 41% in the treatment group and 59% in the control group. Both groups showed a male predominance, and their average age, ethnic distribution and family status were comparable. High unemployment rates and discrimination at work due to HBV status were prevalent, with many patients feeling their career choices were influenced by HBV, particularly among untreated patients. Treated patients reported significantly lower scores in general health perception (41% vs. 13%; <jats:italic>p<\/jats:italic>\u2009=\u2009.06) and limitation of usual activity secondary to CHB (29% vs. 0%; <jats:italic>p<\/jats:italic>\u2009=\u2009.008), resulting in a substantial impact on overall health\u2010related QOL. This study highlights the psychosocial implications of CHB in asymptomatic, noncirrhotic patients, underscoring the importance of comprehensive support and increased awareness. Additionally, addressing challenges related to long\u2010term treatment, such as adherence and cost, may have the potential to improve patient well\u2010being and outcomes.<\/jats:p>","DOI":"10.1111\/jvh.13894","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T07:19:03Z","timestamp":1698995943000},"page":"12-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Chronic hepatitis B beyond clinical burden: Psychosocial effects and impact on quality of life"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-2433","authenticated-orcid":false,"given":"Randa Taher","family":"Natour","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hillel Yaffe Medical Center, Hadera, Israel. Affiliated to the Technion Faculty of Medicine  Haifa Israel"},{"name":"Department of gastroenterology and hepatology Hillel Yaffe Medical Center, Hadera, Israel. Affiliated to the Technion Faculty of Medicine  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Midlej","sequence":"additional","affiliation":[{"name":"Medicine faculty of the Technion Faculty of Medicine  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Mahajna","sequence":"additional","affiliation":[{"name":"Department of gastroenterology and hepatology Hillel Yaffe Medical Center, Hadera, Israel. Affiliated to the Technion Faculty of Medicine  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Kopelman","sequence":"additional","affiliation":[{"name":"Department of gastroenterology and hepatology Hillel Yaffe Medical Center, Hadera, Israel. Affiliated to the Technion Faculty of Medicine  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif","family":"Abo\u2010Mouch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hillel Yaffe Medical Center, Hadera, Israel. Affiliated to the Technion Faculty of Medicine  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi Abu","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of gastroenterology and hepatology Hillel Yaffe Medical Center, Hadera, Israel. 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