{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:47:54Z","timestamp":1782514074141,"version":"3.54.5"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The opioid crisis has adversely affected West Virginia's pregnant and infant populations. With high rates of opioid use disorder and neonatal abstinence syndrome, West Virginia has the highest rates of Hepatitis C (HCV) acute infection among pregnant women. To better understand how HCV impacts an already high\u2010risk population, the study purpose was to (1) describe its prevalence among women receiving prenatal care at a single tertiary care clinic in Appalachia and compare with state and national rates, and (2) determine whether it is associated with preterm birth (gestation &lt;37\u2009weeks). Data were collected on a retrospective cohort of pregnant patients universally screened for HCV between 2017 and 2021. The study cohort had an HCV infection rate of 119\/988\u2009=\u200911.94% or 119.4 per 1000. This is five times the rate of 22.6 per 1000 live births in West Virginia in 2014 and 35 times the national rate of 3.4 per 1000 live births (<jats:italic>MMWR Morb Mortal Wkly Rep<\/jats:italic> 66, 2017 and 470). Viral loads were detected in 63 (6.38%) of patients. The study cohort with birth outcome data had high rates of tobacco use (326\/720; 45.3%) and substance abuse (209\/720; 29.0%). The preterm birth rate was 17.8% (128\/720), almost double the national average (10.09%) (<jats:italic>Natl Vital Stat Rep<\/jats:italic> 70, 2021 and 1). There was no statistically significant difference in preterm birth between HCV\u2010positive (15\/92; 16.3%) and HCV\u2010negative (113\/628; 18.0%) patients. HCV infection in our population presents a significant public health issue and missed opportunity for treatment in a population with continuity of care challenges. These findings could be used to justify a pilot program for early postpartum referral for treatment.<\/jats:p>","DOI":"10.1111\/jvh.13911","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T12:05:51Z","timestamp":1705579551000},"page":"216-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of hepatitis C among pregnant women in an Appalachian population"],"prefix":"10.1111","volume":"31","author":[{"given":"Taylor S.","family":"Pollock","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology West Virginia University \u2013 Charleston Division, Charleston Area Medical Center  Charleston West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris A.","family":"Robert","sequence":"additional","affiliation":[{"name":"CAMC Institute for Academic Medicine  Charleston West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara J.","family":"Seybold","sequence":"additional","affiliation":[{"name":"CAMC Institute for Academic Medicine  Charleston West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Hur","sequence":"additional","affiliation":[{"name":"West Virginia School of Osteopathic Medicine  Lewisburg West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Broton","sequence":"additional","affiliation":[{"name":"West Virginia School of Osteopathic Medicine  Lewisburg West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron C.","family":"Calhoun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West Virginia University \u2013 Charleston Division, Charleston Area Medical Center  Charleston West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12430"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.24770"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6618a3"},{"issue":"17","key":"e_1_2_8_5_1","first-page":"1","article-title":"Births: Final Data for 2020","volume":"70","author":"Osterman M","year":"2021","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002807"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0261-z"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1334459"},{"key":"e_1_2_8_9_1","unstructured":"Centers for Disease Control and Prevention.Too Few People Treated for Hepatitis C.2022. Accessed September 25 2023.https:\/\/www.cdc.gov\/vitalsigns\/hepc\u2010treatment\/index.html"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T07:00:49Z","timestamp":1710572449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,18]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/jvh.13911"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13911","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,18]]},"assertion":[{"value":"2023-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}