{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:39:21Z","timestamp":1790995161567,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic viral hepatitis B (HBV) and C (HCV) infection could negatively affect outcomes of non\u2010hepatic solid organ transplantations due to the risk of viral reactivation in the presence of immunosuppression. This study aimed to determine post\u2010transplant outcomes in patients with HBV or HCV positivity receiving non\u2010hepatic solid\u2010state organ transplant. Data was collected from the Scientific Registry of Transplant Recipients (SRTR) 2006\u20132021 for patients (\u226518) who received a lung, heart, or kidney single organ transplant in the U.S. Hepatitis C positivity (HCV+) was determined as positive HCV Ab and hepatitis B positivity (HBV+) as positive HBsAg. We included\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200930,872 lung,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200936,990 heart and\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009280,162 kidney transplant recipients. The prevalence of HBV+ was 1.3% in lung, 1.5% in heart and 1.7% in kidney patients, HCV+ was 2.2%, 2.2% and 5.0%, respectively. Post\u2010transplant survival of patients with vs. without HBV+ was similar in all solid organ transplants (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u2009.05). Similarly, there was no difference in post\u2010transplant survival between lung transplant recipients with vs. without anti\u2010HCV (all p\u2009&gt;\u2009.05). Heart transplant recipients with HCV+ had higher crude post\u2010transplant mortality (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01). Similarly, there was higher post\u2010transplant mortality in kidney transplant recipients with HCV+ (1\u2010year: 6% vs. 3%; 5\u2010year: 21% vs. 13%; 10\u2010year: 47% vs. 31%; all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001). In multivariate analysis controlling for confounders, only the association of HCV+ with higher post\u2010kidney transplant mortality remained significant: adjusted hazard ratio (aHR) (95% CI)\u2009=\u20091.16 (1.12\u20131.20),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001. There was no association of viral hepatitis seropositivity with the risk of graft failure in all groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u2009.05). In most cases, the presence of HBV or HCV serologies is not associated with adverse post\u2010transplant outcomes in non\u2010hepatic solid organ transplants. However, kidney transplant recipients who are positive for HCV serology have an increased risk for post\u2010transplant mortality.\n                  <\/jats:p>","DOI":"10.1111\/jvh.13916","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T02:55:01Z","timestamp":1703904901000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of hepatitis B and C positive serologies on the outcomes of\n                    <scp>non\u2010hepatic<\/scp>\n                    solid organ transplantation in the United States"],"prefix":"10.1111","volume":"31","author":[{"given":"Saleh A.","family":"Alqahtani","sequence":"first","affiliation":[{"name":"The Global NASH Council  Washington DC USA"},{"name":"Liver Transplant Center and Biostatistics, Epidemiology &amp; Scientific Computing Department King Faisal Specialist Hospital &amp; Research Center  Riyadh Saudi Arabia"},{"name":"Division of Gastroenterology &amp; Hepatology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Stepanova","sequence":"additional","affiliation":[{"name":"The Global NASH Council  Washington DC USA"},{"name":"Liver Transplant Center and Biostatistics, Epidemiology &amp; Scientific Computing Department King Faisal Specialist Hospital &amp; Research Center  Riyadh Saudi Arabia"},{"name":"Division of Gastroenterology &amp; Hepatology Johns Hopkins University  Baltimore Maryland USA"},{"name":"Beatty Liver and Obesity Research Program, Inova Health System  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Al\u00a0Shabeeb","sequence":"additional","affiliation":[{"name":"Beatty Liver and Obesity Research Program, Inova Health System  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine Luz","family":"Eberly","sequence":"additional","affiliation":[{"name":"Beatty Liver and Obesity Research Program, Inova Health System  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janus","family":"Ong","sequence":"additional","affiliation":[{"name":"The Global NASH Council  Washington DC USA"},{"name":"College of Medicine University of the Philippines  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-577X","authenticated-orcid":false,"given":"Zobair M.","family":"Younossi","sequence":"additional","affiliation":[{"name":"The Global NASH Council  Washington DC USA"},{"name":"Beatty Liver and Obesity Research Program, Inova Health System  Falls Church Virginia USA"},{"name":"Center for Outcomes Research in Liver Diseases  Washington DC 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