{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:47:54Z","timestamp":1782514074013,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eliminating hepatitis C virus (HCV) infection in the population of women of reproductive age is important not only for the health of women themselves but also for the health of newborns. This study aimed to evaluate the implementation of this goal by analysing the effectiveness of contemporary therapy in a large cohort from everyday clinical practice along with identifying factors reducing therapeutic success. The analysed population consisted of 7861 patients, including 3388 women aged 15\u201349, treated in 2015\u20132022 in 26 hepatology centres. Data were collected retrospectively using a nationwide EpiTer\u20102 database. Females were significantly less often infected with HCV genotype 3 compared to males (11.2% vs. 15.7%) and less frequently showed comorbidities (40.5% vs. 44.2%) and comedications (37.2% vs. 45.2%). Hepatocellular carcinoma, liver transplantation, HIV and HBV coinfections were reported significantly less frequently in women. Regardless of the treatment type, females significantly more often reached sustained virologic response (98.8%) compared to males (96.8%). Regardless of gender, genotype 3 and cirrhosis were independent factors increasing the risk of treatment failure. Women more commonly reported adverse events, but death occurred significantly more frequently in men (0.3% vs. 0.1%), usually related to underlying advanced liver disease. We have demonstrated excellent effectiveness and safety profiles for treating HCV infection in women. This gives hope for the micro\u2010elimination of HCV infections in women, translating into a reduced risk of severe disease in both women and their children.<\/jats:p>","DOI":"10.1111\/jvh.13936","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:55:56Z","timestamp":1710410156000},"page":"309-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Direct\u2010acting antivirals in women of reproductive age infected with hepatitis C virus"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0352-9893","authenticated-orcid":false,"given":"Krystyna","family":"Dobrowolska","sequence":"first","affiliation":[{"name":"Collegium Medicum Jan Kochanowski University  Kielce Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Paw\u0142owska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology, Faculty of Medicine Collegium Medicum Bydgoszcz, Nicolaus Copernicus University  Toru\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0938-1084","authenticated-orcid":false,"given":"Dorota","family":"Zar\u0119bska\u2010Michaluk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Allergology Jan Kochanowski University  Kielce Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4713-0801","authenticated-orcid":false,"given":"Piotr","family":"Rzymski","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine Pozna\u0144 University of Medical Sciences  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5406-4603","authenticated-orcid":false,"given":"Ewa","family":"Janczewska","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, School of Public Health in Bytom Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Tudrujek\u2010Zdunek","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Berak","sequence":"additional","affiliation":[{"name":"Outpatient Clinic Hospital for Infectious Diseases in Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W\u0142odzimierz","family":"Mazur","sequence":"additional","affiliation":[{"name":"Clinical Department of Infectious Diseases in Chorz\u00f3w Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Klapaczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Hepatology The National Institute of Medicine of the Ministry of Interior and Administration  Warszawa Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Lorenc","sequence":"additional","affiliation":[{"name":"Pomeranian Center of Infectious Diseases, Medical University  Gda\u0144sk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Janocha\u2010Litwin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Wroc\u0142aw Medical University  Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3815-3745","authenticated-orcid":false,"given":"Anna","family":"Parfieniuk\u2010Kowerda","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bia\u0142ystok  Bia\u0142ystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Dybowska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology, Faculty of Medicine Collegium Medicum Bydgoszcz, Nicolaus Copernicus University  Toru\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Piekarska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Krygier","sequence":"additional","affiliation":[{"name":"Outpatients Hepatology Department State University of Applied Sciences  Konin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Dobracka","sequence":"additional","affiliation":[{"name":"MedicalSpec Medical Center  Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Jaroszewicz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Silesia in Katowice  Bytom Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Flisiak","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bia\u0142ystok  Bia\u0142ystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6839a1"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102327"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02539.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2017.22.2.30441"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.11.013"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.08.019"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.027"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.24770"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12960-019-0406-0"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2015-102879"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S380952"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu057"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.101931"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.16094"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1140485"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2001.tb01089.x"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1386.007"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14081806"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)01259-8"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044624"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12070984"},{"key":"e_1_2_13_23_1","unstructured":"World Health Organization.Women of reproductive age (15\u201349\u2009years) population (thousands). Accessed November 15 2023.https:\/\/www.who.int\/data\/gho\/indicator\u2010metadata\u2010registry\/imr\u2010details\/women\u2010of\u2010reproductive\u2010age\u2010(15\u201049\u2010years)\u2010population\u2010(thousands)"},{"issue":"2","key":"e_1_2_13_24_1","first-page":"47","article-title":"Recommendations for the treatment of hepatitis C in 2017","volume":"3","author":"Polish Group of Experts for HCV","year":"2017","journal-title":"Clin Exp Hepatol"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2020.98606"},{"issue":"2","key":"e_1_2_13_26_1","first-page":"27","article-title":"Recommendations for the treatment of hepatitis C issued by the polish group of HCV experts \u2013 2016","volume":"2","author":"Polish Group of HCV Experts","year":"2016","journal-title":"Clin Exp Hepatol"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.31350\/zakazenia\/2019\/2\/Z2019014"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.31350\/zakazenia\/2018\/3\/Z2018019"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2023.125957"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.025"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30359-9"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30791"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2016.07.004"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad319"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268817001947"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu447"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.05.044"},{"issue":"4","key":"e_1_2_13_38_1","first-page":"134","article-title":"Safety and efficacy of treatment for chronic hepatitis C during pregnancy: a prospective observational study in Srinagar, India","volume":"22","author":"Yattoo GN","year":"2023","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2018.05.029"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(20)30062-8"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.07.017"},{"key":"e_1_2_13_42_1","unstructured":"AASLD.Late\u2010Breaking Abstracts.2023. Accessed February 12 2024.https:\/\/www.aasld.org\/sites\/default\/files\/2023\u201011\/SLD\u2010625"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13901"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2018.07.004"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2018-0233"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1601160"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14537"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i6.949"},{"issue":"2","key":"e_1_2_13_49_1","first-page":"163","article-title":"Changes in patient profile, treatment effectiveness, and safety during 4\u2009years of access to interferon\u2010free therapy for hepatitis C virus infection","volume":"130","author":"Flisiak R","year":"2020","journal-title":"Pol Arch Intern med"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24618"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.20517\/2394-5079.2015.53"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.1082183"},{"key":"e_1_2_13_53_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction.Poland country drug report 2019. Accessed February 6 2024.https:\/\/www.emcdda.europa.eu\/publications\/country\u2010drug\u2010reports\/2019\/poland_en"},{"key":"e_1_2_13_54_1","unstructured":"United Nations: Office on Drugs and Crime.World drug report 2023.2023. Accessed February 6 2024.https:\/\/www.unodc.org\/unodc\/en\/data\u2010and\u2010analysis\/world\u2010drug\u2010report\u20102023.html"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T15:28:12Z","timestamp":1715959692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,14]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/jvh.13936"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13936","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,14]]},"assertion":[{"value":"2024-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}