{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:40:59Z","timestamp":1747186859828,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Limited data exist regarding the association between hepatitis B virus (HBV) DNA levels and liver histopathological changes in patients with chronic hepatitis B (CHB) during the immune tolerant (IT) phase. In this study, we retrospectively analysed liver biopsy results from 150 adult IT\u2010CHB patients. The liver tissue necroinflammation and fibrosis were evaluated by the Scheuer scoring system. Multivariate logistic regression, smooth curve fitting, and segmented regression models were used to examine the association between HBV DNA levels and liver histopathological changes. A total of 26%, 30.67% and 42% of IT patients had significant necroinflammation (\u2265G2), significant fibrosis (\u2265S2) and significant histopathological changes (\u2265G2 and\/or \u2265S2), respectively. HBV DNA levels were independently and non\u2010linear inversely associated with significant necroinflammation and histopathological changes in IT\u2010CHB patients. Patients with HBV DNA levels &lt;10<jats:sup>7<\/jats:sup>\u2009IU\/mL had a higher risk of significant histopathological changes compared to those with levels &gt;10<jats:sup>7<\/jats:sup>\u2009IU\/mL. The findings were further confirmed by smooth curve fitting analyses, subgroup and sensitivity analyses. In segmented regression model analyses, the optimal DNA value for the lowest odds ratio of significant histopathological changes was 7.26 log10\u2009IU\/mL. A non\u2010linear inverse association between HBV DNA levels and significant histopathological changes in IT\u2010CHB patients. DNA 7.26 log10\u2009IU\/mL may serve as a potential cut\u2010off point to define a \u2018true immune tolerant phase\u2019 with minimal liver histopathological changes.<\/jats:p>","DOI":"10.1111\/jvh.13940","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T06:08:25Z","timestamp":1712383705000},"page":"363-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inverse relationship between <scp>HBV DNA<\/scp> levels and liver histopathological changes in immune\u2010tolerant <scp>CHB<\/scp> patients"],"prefix":"10.1111","volume":"31","author":[{"given":"Deliang","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Liver Diseases, The Third People's Hospital of Shenzhen The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen Guangdong 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