{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:38:34Z","timestamp":1781642314151,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is an urgent need for new high\u2010quality markers for the early detection of hepatocellular carcinoma (HCC). \u00c5str\u00f6m et\u00a0al. suggested that S2\u2010bound \u03b11\u2010acid glycoprotein (AGP) might be a promising marker. Consequently, we evaluated the predictive advantage of S2\u2010bound AGP in the early detection of HCC. In a retrospective case\u2013control study of patients chronically infected with hepatitis C virus (HCV) and treated with direct\u2010acting antiviral agents (<jats:italic>n<\/jats:italic>\u2009=\u200993), we measured S2\u2010bound AGP using the HepaCheC\u00ae ELISA kit (Glycobond AB, Link\u00f6ping, SE) at the start of treatment, end of treatment and follow\u2010up (maximum: 78\u2009months). Patients were retrospectively propensity score matched (1:2). Thirty\u2010one patients chronically infected with HCV developed HCC after a sustained virological response, while 62 did not. In addition, samples of patients with chronic hepatitis B virus infection, metabolic dysfunction\u2010associated steatotic liver disease and HCC of different etiologies were analysed. S2\u2010bound AGP elevation in HCC patients was confirmed. However, we did not observe a predictive advantage of S2\u2010bound AGP for the early detection of HCC during treatment and follow\u2010up. Interestingly, S2\u2010bound AGP levels correlated with aspartate aminotransferase (\u03c1\u2009=\u2009.56, <jats:italic>p<\/jats:italic>\u2009=\u20099.5\u00d710<jats:sup>\u221215<\/jats:sup>) and liver elastography (\u03c1\u2009=\u2009.67, <jats:italic>p<\/jats:italic>\u2009=\u20092.2\u00d710<jats:sup>\u221216<\/jats:sup>). Of note, S2\u2010bound AGP decreased in patients chronically infected with HCV after treatment\u2010induced HCV clearance. Fucosylated S2\u2010bound AGP levels were elevated in patients with chronic HCV and HCC. The potential role of S2\u2010bound AGP as a novel tumour marker requires further investigation.<\/jats:p>","DOI":"10.1111\/jvh.13943","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T04:34:35Z","timestamp":1712982875000},"page":"383-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Elevation of <scp>S2<\/scp>\u2010bound \u03b11\u2010acid glycoprotein is associated with chronic hepatitis C virus infection and hepatocellular carcinoma"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-9854","authenticated-orcid":false,"given":"Carlos","family":"Oltmanns","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School (MHH)  Hannover Germany"},{"name":"Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH)  Hannover Germany"},{"name":"Cluster of Excellence Resolving Infection Susceptibility (RESIST; EXC 2155), Hannover Medical School  Hannover Germany"},{"name":"TWINCORE, a joint venture between the Helmholtz\u2010Centre for Infection Research (HZI) and the Hannover Medical School (MHH)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Bremer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School (MHH)  Hannover Germany"},{"name":"Cluster of Excellence Resolving Infection Susceptibility (RESIST; EXC 2155), Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kusche","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School (MHH)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"St\u00e5l","sequence":"additional","affiliation":[{"name":"Department of Medicine Karolinska Institutet  Huddinge Sweden"},{"name":"Division of Hepatology, Department of Upper GI Diseases Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Zenlander","sequence":"additional","affiliation":[{"name":"Department of Medicine Karolinska Institutet  Huddinge Sweden"},{"name":"Department of Clinical Chemistry Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Laboratory Medicine Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tauwaldt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School (MHH)  Hannover Germany"},{"name":"Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH)  Hannover Germany"},{"name":"Cluster of Excellence Resolving Infection Susceptibility (RESIST; EXC 2155), Hannover Medical School  Hannover Germany"},{"name":"TWINCORE, a joint venture between the Helmholtz\u2010Centre for Infection Research (HZI) and the Hannover Medical School (MHH)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvar","family":"Ryd\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"P\u00e5hlsson","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-8001","authenticated-orcid":false,"given":"Markus","family":"Cornberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School (MHH)  Hannover Germany"},{"name":"Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH)  Hannover Germany"},{"name":"Cluster of Excellence Resolving Infection Susceptibility (RESIST; EXC 2155), Hannover Medical School  Hannover Germany"},{"name":"TWINCORE, a joint venture between the Helmholtz\u2010Centre for Infection Research (HZI) and the Hannover Medical School (MHH)  Hannover Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Hannover\u2010Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School (MHH)  Hannover Germany"},{"name":"Cluster of Excellence Resolving Infection Susceptibility (RESIST; EXC 2155), Hannover Medical School  Hannover Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Hannover\u2010Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.01.023"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001624"},{"issue":"1","key":"e_1_2_13_5_1","first-page":"115","article-title":"Biomarkers for hepatobiliary cancers","volume":"73","author":"Nault J","year":"2020","journal-title":"Hepatology"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.08.025"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10018-1268"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.064"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.01.047"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01882.x"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012419"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2014-0427"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173897"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v042.i08"},{"issue":"1","key":"e_1_2_13_15_1","first-page":"18","article-title":"A step\u2010by\u2010step guide to propensity score matching in R","volume":"19","author":"Randolph JJ","year":"2014","journal-title":"Pract Assess Res Eval"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001400"},{"issue":"1","key":"e_1_2_13_17_1","first-page":"43","article-title":"Decrease of alpha\u2010fetoprotein in patients with cirrhosis treated with direct\u2010acting antivirals","volume":"5","author":"Nguyen K","year":"2017","journal-title":"J Clin Transl Hepatol"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14080735"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2020.01.014"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061370"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.08.042"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T07:45:09Z","timestamp":1718091909000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,12]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/jvh.13943"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13943","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,12]]},"assertion":[{"value":"2024-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}