{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:41:02Z","timestamp":1747186862151,"version":"3.40.5"},"reference-count":8,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The understanding of viral transcription and replication activity in HBeAg\u2010positive chronic hepatitis B (CHB) patients with low\u2010level viraemia (LLV) or previous low\u2010level viraemia (pre\u2010LLV) remains unclear. Our aim was to evaluate and compare circulating hepatitis B virus (HBV) RNA levels in these patient groups with those achieving maintained virological response (MVR). This cross\u2010sectional study included 147 patients: 43 in the LLV group, 25 in the pre\u2010LLV group and 79 in the MVR group. Serum HBV RNA levels were assessed using specific RNA target capture combined with simultaneous amplification and testing method. Propensity score matching (PSM) was used to balance baseline characteristics between groups. Median HBV RNA levels were 6.9\u2009copies\/mL in the LLV group, 6.1\u2009copies\/mL in the pre\u2010LLV group and 3.8\u2009copies\/mL in the MVR group. After PSM, significantly higher HBV RNA levels were observed in the LLV group compared to the MVR group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and the pre\u2010LLV group also showed higher HBV RNA levels than the MVR group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Both LLV and pre\u2010LLV HBeAg\u2010positive CHB patients exhibited elevated circulating HBV RNA levels compared to those achieving MVR.<\/jats:p>","DOI":"10.1111\/jvh.13957","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T09:54:59Z","timestamp":1718013299000},"page":"504-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Elevated hepatitis B virus <scp>RNA<\/scp> levels in <scp>HBeAg<\/scp>\u2010positive patients with low\u2010level viraemia or previous low\u2010level viraemia"],"prefix":"10.1111","volume":"31","author":[{"given":"Tao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Infectious Disease and Hepatology The Second Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Hepatology The Second Hospital of Shandong University  Jinan China"},{"name":"Department of Gastroenterology Yidu Central Hospital of Weifang  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Hepatology The Second Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Hepatology The Second Hospital of Shandong University  Jinan China"},{"name":"Department of Gastroenterology Hospital of Traditional Chinese Medicine of Linyi City  Linyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Hepatology The Second Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8240-9795","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Hepatology The Second Hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.03.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28916"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002181"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-0966-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.12.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32479"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2211764"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T09:13:53Z","timestamp":1724922833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/jvh.13957"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13957","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"type":"print","value":"1352-0504"},{"type":"electronic","value":"1365-2893"}],"subject":[],"published":{"date-parts":[[2024,6,10]]},"assertion":[{"value":"2023-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}