{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:41:03Z","timestamp":1747186863064,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>On March 31, 2022, severe acute hepatitis of unknown origin was first reported from the Royal Glasgow Children's Hospital in Scotland. According to the criteria by WHO\u2010ECDC, a probable case of unknown acute hepatitis in children is defined as a subject under 16\u2009years of age, who tested negative for viral hepatitis and transaminases &gt;500\u2009U\/L, starting from the 1st of October 2021. WHO invites Member States to participate in the global effort to collect anonymized clinical data on probable cases of severe acute hepatitis of unknown aetiology. As of May 26, 2021, 650 cases were already registered on the platform worldwide, of whom at least 38 cases have required liver transplants. Several hypotheses such as previous SARS\u2010CoV\u20102 infection or coinfection or infection with another virus were examined and a strong association was found between adenovirus (41F) and acute hepatitis of unknown aetiology cases. This review article summarizes the global epidemiological evidences on acute hepatitis of unknown origin in children, analysing their incidence and characteristics.<\/jats:p>","DOI":"10.1111\/jvh.13978","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T10:15:03Z","timestamp":1722248103000},"page":"577-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe acute hepatitis of unknown origin in children: Is it still a\u00a0mystery? What role does adenovirus play?"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9146-9968","authenticated-orcid":false,"given":"Cristina","family":"Stasi","sequence":"first","affiliation":[{"name":"Epidemiology Unit, Regional Health Agency of Tuscany  Florence Italy"},{"name":"Department of Medical, Surgical and Neuroscience Sciences University of Siena  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Pacifici","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Regional Health Agency of Tuscany  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monia","family":"Puglia","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Regional Health Agency of Tuscany  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Voller","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Regional Health Agency of Tuscany  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2022.27.15.2200318"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16665"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.03.005"},{"key":"e_1_2_13_5_1","unstructured":"European Centre for Disease Prevention and Control and World Health Organization.Joint ECDC\u2010WHO Regional Office for Europe Hepatitis of Unknown Origin in in Children surveillance bulletin.2022."},{"key":"e_1_2_13_6_1","unstructured":"World Health Organization Disease Outbreak News.Multi\u2010Country \u2013 acute severe hepatitis of unknown origin in children.2022.https:\/\/www.who.int\/emergencies\/disease\u2010outbreak\u2010news\/item\/DON\u2010389"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1056385"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2022.27.19.2200370"},{"key":"e_1_2_13_9_1","unstructured":"Centers for Disease Control and Prevention.Technical Report: Acute Hepatitis of Unknown Cause.2022Available at:https:\/\/www.cdc.gov\/ncird\/investigation\/hepatitis\u2010unknown\u2010cause\/technical\u2010report.html"},{"key":"e_1_2_13_10_1","unstructured":"World Health Organization.Severe acute hepatitis of unknown aetiology in children \u2010 Multi\u2010country.2022Available at: at:https:\/\/www.who.int\/emergencies\/disease\u2010outbreaknews\/item\/2022\u2010 DON400#:~:text=Description%20of%20the%20Situation&text=As%20of%208%20July%2 02022 case%20definition%2C%20including%2022%20deaths"},{"key":"e_1_2_13_11_1","unstructured":"European Centre for Disease Prevention and Control.Technical report. Guidance for diagnostic testing of cases with severe acute hepatitis of unknown aetiology in children.2022."},{"key":"e_1_2_13_12_1","unstructured":"World Health Organization.The WHO Global Clinical Platform for severe acute hepatitis of unknown aetiology in children.2022."},{"key":"e_1_2_13_13_1","unstructured":"Circolare del 23 maggio 2022 del Ministero della Salute.https:\/\/www.trovanorme.salute.gov.it\/norme\/renderNormsanPdf?anno=2022&codLeg=87356&parte=1%20&serie=null"},{"key":"e_1_2_13_14_1","unstructured":"NgV ScienceM FeldJ et\u00a0al.COVID\u201019 advisory for Ontario. 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