{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:04:51Z","timestamp":1783544691014,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HCV infection poses a global health threat, with significant morbidity and mortality. This study examines HCV trends in a large Italian region from 2015 to 2022, considering demographic changes, evolving clinical profiles, treatment regimens and outcomes, including the impact of the COVID\u201019 pandemic. This multicentre retrospective study analysed demographics, clinical histories and risk factors in 6882 HCV patients. The study spanned before and after the direct\u2010acting antiviral (DAA) era, and the COVID\u201019 period, focusing on treatment outcomes (SVR12, non\u2010SVR12 and patients lost to follow\u2010up). Statistical methods included ANOVA, multinomial logistic regression, Kruskal\u2013Wallis test and chi\u2010square analysis, and were conducted adhering to the intention\u2010to\u2010treat (ITT) principle. The cohort, mainly Italian males (average age 58.88), showed Genotype 1 dominance (56.6%) and a high SVR12 rate (97.5%). The pandemic increased follow\u2010up losses, yet SVR12 rates remained stable, influenced by factors like age, gender, cirrhosis and comorbidities. Despite COVID\u201019 challenges, the region sustained high SVR12 rates in HCV care, emphasising the importance of sustained efforts in HCV care. Continuous screening and targeted interventions in high\u2010risk populations are crucial for achieving WHO elimination targets. The study highlights the resilience of HCV care during the pandemic and provides insights for future public health strategies.<\/jats:p>","DOI":"10.1111\/jvh.13983","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T19:25:31Z","timestamp":1722108331000},"page":"623-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hepatitis C epidemiology and treatment outcomes in Italy: Impact of the <scp>DAA<\/scp> era and the <scp>COVID<\/scp>\u201019 pandemic"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5146-4997","authenticated-orcid":false,"given":"Maria Paola","family":"Tramonti Fantozzi","sequence":"first","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Ceccarelli","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"},{"name":"Sant'Anna School of Advanced Studies  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Petri","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2659-0905","authenticated-orcid":false,"given":"Erica","family":"De\u00a0Vita","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Agostini","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Colombatto","sequence":"additional","affiliation":[{"name":"Hepatology Unit Pisa University Hospital  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9146-9968","authenticated-orcid":false,"given":"Cristina","family":"Stasi","sequence":"additional","affiliation":[{"name":"CRIA\u2010MASVE Center for Research and Innovation Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Rossetti","sequence":"additional","affiliation":[{"name":"AUSL Toscana Sud Est Grosseto Hospital  Grosseto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizia","family":"Brunetto","sequence":"additional","affiliation":[{"name":"Hepatology Unit Pisa University Hospital  Pisa Italy"},{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Surace","sequence":"additional","affiliation":[{"name":"Hepatology Unit Pisa University Hospital  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Salvati","sequence":"additional","affiliation":[{"name":"Hepatology Unit Pisa University Hospital  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Cal\u00ec","sequence":"additional","affiliation":[{"name":"Hepatology Unit Pisa University Hospital  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Tacconi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Arezzo Hospital  Arezzo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bianco","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Arezzo Hospital  Arezzo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Redi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Arezzo Hospital  Arezzo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-812X","authenticated-orcid":false,"given":"Massimiliano","family":"Fabbiani","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Panza","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit Siena University Hospital  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sauro","family":"Luchi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hepatology San Luca Hospital, AUSL Toscana Nord Ovest  Lucca Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Modica","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hepatology San Luca Hospital, AUSL Toscana Nord Ovest  Lucca Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Moneta","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hepatology San Luca Hospital, AUSL Toscana Nord Ovest  Lucca Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Iacopini","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hepatology San Luca Hospital, AUSL Toscana Nord Ovest  Lucca Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesira","family":"Nencioni","sequence":"additional","affiliation":[{"name":"AUSL Toscana Sud Est Grosseto Hospital  Grosseto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Chigiotti","sequence":"additional","affiliation":[{"name":"AUSL Toscana Sud Est Grosseto Hospital  Grosseto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ottaviano","sequence":"additional","affiliation":[{"name":"AUSL Toscana Sud Est Grosseto Hospital  Grosseto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-4166","authenticated-orcid":false,"given":"Anna Linda","family":"Zignego","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Blanc","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases 1\u20102 AUSL Toscana Centro  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Pierotti","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases 1\u20102 AUSL Toscana Centro  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Mariabelli","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases 1\u20102 AUSL Toscana Centro  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Berni","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Tuscany Regional Health Agency  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Tuscany Regional Health Agency  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2217-4664","authenticated-orcid":false,"given":"Lara","family":"Tavoschi","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"S21","article-title":"Understanding hepatitis C","volume":"10","author":"McHutchison JG","year":"2004","journal-title":"Am J Manag Care"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.013"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00386-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268817001947"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2019.24.30.1800614"},{"key":"e_1_2_11_7_1","first-page":"249","article-title":"Prevalence of hepatitis C virus estimates of undiagnosed individuals in different Italian regions: a mathematical modelling approach by route of transmission and fibrosis progression with results up to January 2021","volume":"45","author":"Kondili LA","year":"2022","journal-title":"New Microbiol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.02.015"},{"key":"e_1_2_11_9_1","unstructured":"Mele A.;Tosti M.E.;Spada E.;Mariano A.;Bianco E.;SEIEVA collaborative group epidemiology of acute viral hepatitis: twenty years of surveillance through SEIEVA in Italy and a Review of the Literature2005."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i44.9829"},{"key":"e_1_2_11_11_1","volume-title":"Epidemiologia Dell'infezione Cronica Da HCV in Toscana","author":"Stasi C.","year":"2017"},{"key":"e_1_2_11_12_1","unstructured":"WHO Global Health Sector Strategy on Viral Hepatitis.Towards Ending Viral Hepatitis Available online.2016\u20132021. Accessed 26 January 2024https:\/\/www.who.int\/publications\u2010detail\u2010redirect\/WHO\u2010HIV\u20102016.06"},{"key":"e_1_2_11_13_1","unstructured":"WHO.Action Plan for the Health Sector Response to Viral Hepatitis in the WHO European Region. Accessed 26 January 2024.https:\/\/www.who.int\/europe\/publications\/i\/item\/9789289052870"},{"key":"e_1_2_11_14_1","unstructured":"Ministero della Salute Piano nazionale per la prevenzione delle epatiti virali da virus B e C (PNEV). Accessed on 26 January 2024https:\/\/www.salute.gov.it\/portale\/documentazione\/p6_2_2_1.jsp?id=2437&lingua=italiano"},{"key":"e_1_2_11_15_1","unstructured":"Italian Medicine Agency Aggiornamento Epatite C. Accessed on 27 January 2024https:\/\/www.aifa.gov.it\/aggiornamento\u2010epatite\u2010c"},{"key":"e_1_2_11_16_1","unstructured":"Italian Medicine Agency Redefinition of Treatment Criteria for Chronic HCV Therapy (Determina n. 500\/2017)."},{"key":"e_1_2_11_17_1","unstructured":"Regional Council of Tuscany Region Abstract of the Minutes of the Meeting of 09.04.2018.Subject: Project for the Implementation of a Program for the Control of Chronic Hepatitis C in Tuscany (DGR397\/2018)."},{"key":"e_1_2_11_18_1","unstructured":"Regional Council of Tuscany Region Launch of a Free Screening Programme to Prevent.Eliminate and Eradicate the Hepatitis C Virus in Implementation of Art. 25\u2010Sexies of D.L.n. 162\/2019. Approval of the Project."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020192437"},{"key":"e_1_2_11_20_1","first-page":"1","article-title":"Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945\u20131965","volume":"61","author":"Smith BD","year":"2012","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-157-9-201211060-00529"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2018.1482264"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-S5-S2"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348506"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363386"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27259"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.07.042"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1646"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2022.114698"},{"key":"e_1_2_11_30_1","volume-title":"European Centre for Disease Prevention and Control Considerations Relating to Social Distancing Measures in Response to COVID\u201019\u2014Second Update","year":"2020"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1429-3"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.86569"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1325869"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12754"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56030101"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232773"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2991\/jegh.k.200117.002"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1068-3056"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100462"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12579"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.53854\/liim-3103-11"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.26048"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(23)00267-9"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.07.042"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0272609"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13399"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12954-023-00801-1"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T10:08:31Z","timestamp":1732097311000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,27]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/jvh.13983"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13983","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,27]]},"assertion":[{"value":"2024-02-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}