{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:32:32Z","timestamp":1790332352806,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recent studies suggested that successful clearance of chronic Hepatitis C Virus (HCV) by using direct\u2010acting antiviral (DAA) agents could improve glycemic control in patients with diabetes; however, some studies failed to identify this benefit. We conducted a systematic review and meta\u2010analysis to assess the impact of sustained virologic response (SVR) after treatment with DAA agents on glycemic control. Embase, Scopus and PubMed were searched through March 26th, 2023, for all studies evaluating whether eradication of HCV infection with DAAs is associated with an impact on glycemic control. Only studies with data on glycemic control, including haemoglobin A\n                    <jats:sub>1<\/jats:sub>\n                    c (HbA\n                    <jats:sub>1<\/jats:sub>\n                    c), fasting glucose, or Homeostatic Model Assessment for Insulin Resistance (HOMA\u2010IR), at least 12\u2010week post\u2010SVR were included. Sixteen studies met our eligibility criteria and were included in qualitative analysis. The mean HbA\n                    <jats:sub>1<\/jats:sub>\n                    c was 8.05% (95% CI: 7.79%\u20138.31%) before treatment and 7.19% (95% CI: 6.98%\u20137.39%) after treatment. There was a significant mean absolute reduction in HbA1c of 0.72% (95% CI: 0.52%\u20130.93%) with high heterogeneity between studies (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200991.7%). The reduction in HbA1c remained significant in the subgroup analysis at 3\u2009months follow up post SVR [0.74% (95% CI: 0.57%\u20130.91%)] and at least 6\u2009months follow up [0.66% (95% CI: 0.23%\u20131.10%)]. We found a significant reduction in HbA\n                    <jats:sub>1<\/jats:sub>\n                    C after SVR in patients with type 2 diabetes mellitus, reflecting better glycemic control with HCV eradication. This data highlights an important extrahepatic benefit of HCV eradication.\n                  <\/jats:p>","DOI":"10.1111\/jvh.13984","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T08:19:46Z","timestamp":1721809186000},"page":"633-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The role of treatment of hepatitis C with direct\u2010acting antiviral agents on glycaemic control in diabetic patients: An updated systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"31","author":[{"given":"Bing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Geisinger Medical Center  Danville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umair","family":"Iqbal","sequence":"additional","affiliation":[{"name":"WellSpan Health  York Pennsylvania 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