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The study aimed to determine whether such a short therapy will enable achieving a sustained virological response under real\u2010world experience. The study population of 97 patients who discontinued DAA therapy and had data enabling analysis of patient and disease characteristics, and assessment of treatment effectiveness was selected from 16,815 patients registered in the EpiTer\u20102 database. The most common reason for discontinuation was hepatic decompensation (20.6%) or the patient's personal decision (18.6%). Patients who discontinued treatment were significantly older, more frequently therapy\u2010experienced, more likely to have cirrhosis, a history of decompensation and a Child\u2013Pugh B or C classification than those who completed treatment. SVR was achieved by 93.5% of patients who discontinued treatment after 4\u2009weeks, 60.9% if discontinued at 3 or 4\u2009week and 33.3% at Week 1 or 2. Patients receiving pangenotypic but not genotype\u2010specific treatment who discontinued after 4\u2009weeks were as likely to achieve SVR as those who completed therapy. Patients who responded to treatment that lasted no longer than 2\u2009weeks had a low baseline viral load (&lt;400,000\u2009IU\/mL). Despite discontinuation of therapy after Week 4, the chances of SVR are high. Very early discontinuation does not preclude therapeutic success, especially in patients with low baseline viral load.<\/jats:p>","DOI":"10.1111\/jvh.13991","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T11:39:14Z","timestamp":1723030754000},"page":"677-685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sustained Virological Response After Early Discontinuation of Hepatitis C Treatment"],"prefix":"10.1111","volume":"31","author":[{"given":"Robert","family":"Flisiak","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bia\u0142ystok  Bia\u0142ystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0938-1084","authenticated-orcid":false,"given":"Dorota","family":"Zar\u0119bska\u2010Michaluk","sequence":"additional","affiliation":[{"name":"Department of Infectious 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