{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T03:07:51Z","timestamp":1768705671149,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Current US guidelines recommend risk\u2010based testing for hepatitis delta virus (HDV) in persons with chronic hepatitis B (CHB). While there is debate as to whether a risk\u2010based or universal testing approach is most effective, limited data exist on universal HDV testing programs in the United States. We performed a 1\u2010year pilot study evaluating the outcomes of a universal HDV testing approach among US veterans with CHB. All consecutive adults with CHB receiving care at hepatology clinics at a single\u2010centre Veterans Affairs Health System from 1 October 2022 to 30 September 2023 were prospectively tested for anti\u2010HDV antibody (anti\u2010HDV). Patients who were anti\u2010HDV Ab\u2010positive were subsequently tested for HDV RNA. Comparison of HDV testing between groups utilised chi\u2010square testing. A total of 91 consecutive CHB patients (90.0% male, mean age 60.9\u2009\u00b1\u200914.1\u2009years, 73.9% Asian, 26.1% non\u2010Asia, 16.5% cirrhosis and 17.1% with active or past history of drug use) had anti\u2010HDV ordered. Overall, 76.9% (<jats:italic>n<\/jats:italic>\u2009=\u200970) completed anti\u2010HDV testing; 4.3% (<jats:italic>n<\/jats:italic>\u2009=\u20093) were positive. HDV RNA testing was ordered in all three patients; two patients completed HDV RNA testing and one had detectable HDV RNA. No significant differences in completion of anti\u2010HDV testing was observed by age, sex, race\/ethnicity, cirrhosis status or drug use history. Among a single\u2010centre prospective cohort study piloting a universal HDV testing approach, one patient with viremic HDV was identified. Implementing true reflex testing of all CHB patients with anti\u2010HDV, followed by automated HDV RNA testing for anti\u2010HDV\u2010positive patients would improve the HDV testing cascade and timely diagnosis of HDV.<\/jats:p>","DOI":"10.1111\/jvh.13992","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T10:13:48Z","timestamp":1722852828000},"page":"768-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes of a 1\u2010Year Pilot Study Implementing Universal Hepatitis Delta Virus Testing Among Veterans With Chronic Hepatitis B"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8923-2806","authenticated-orcid":false,"given":"Robert\u00a0J.","family":"Wong","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Section Veterans Affairs Palo Alto Healthcare System  Palo Alto California USA"},{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meimei","family":"Liao","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Section Veterans Affairs Palo Alto Healthcare System  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Section Veterans Affairs Palo Alto Healthcare System  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Kwan","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Section Veterans Affairs Palo Alto Healthcare System  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Section Veterans Affairs Palo Alto Healthcare System  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice\u00a0H.","family":"Jou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Oregon Health &amp; Science University Hospital  Portland Oregon USA"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Portland VA Medical Center  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1126-8128","authenticated-orcid":false,"given":"Joseph\u00a0K.","family":"Lim","sequence":"additional","affiliation":[{"name":"Section of Digestive Diseases and Yale Liver Center Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramsey","family":"Cheung","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Section Veterans Affairs Palo Alto Healthcare System  Palo Alto California USA"},{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000642"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001947"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100547"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15746"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000687"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.10.043"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13779"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd17.200324"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T07:27:38Z","timestamp":1729582058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,5]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/jvh.13992"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13992","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,5]]},"assertion":[{"value":"2024-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}