{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:12:40Z","timestamp":1768875160596,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:00:00Z","timestamp":1723334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006692","name":"Universit\u00e0 degli Studi di Torino","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"ABSTRACT<\/jats:title>Micro\u2010RNAs (miRNAs) are involved in the modulation of viral replication and host immune antiviral response. Using next\u2010generation sequencing, we investigated the miRNome profile of circulating extracellular vesicles in 20 patients with chronic hepatitis D virus (HDV) infection undergoing pegylated interferon alpha (Peg\u2010IFN\u03b1) treatment. Circulating miRNAs' expression was analysed according to virologic response (i.e., HDV RNA clearance maintained at least 6\u2009months after the end of therapy). Overall, 8 patients (40%) achieved a virologic response to Peg\u2010IFN\u03b1 treatment. At baseline, 14 miRNAs were differentially expressed between responders and non\u2010responders; after 6\u2009months of Peg\u2010IFN\u03b1 treatment, 7 miRNAs (miR\u2010155\u20105p, miR\u20101246, miR\u2010423\u20103p, miR\u2010760, miR\u2010744\u20105p, miR\u20101307\u20103p and miR\u2010146a\u20105p) were consistently de\u2010regulated. Among de\u2010regulated miRNAs, miR\u2010155\u20105p showed an inverse correlation with HDV RNA (at baseline: r<\/jats:italic>s<\/jats:sub>\u2009=\u2009\u22120.39, p<\/jats:italic>\u2009=\u20090.092; at 6\u2009months: r<\/jats:italic>s<\/jats:sub>\u2009=\u2009\u22120.53, p<\/jats:italic>\u2009=\u20090.016) and hepatitis B surface antigen (HBsAg) (at baseline: r<\/jats:italic>s<\/jats:sub>\u2009=\u2009\u22120.49, p<\/jats:italic>\u2009=\u20090.028; at 6\u2009months: r<\/jats:italic>s<\/jats:sub>\u22120.71, p<\/jats:italic>\u2009<\u20090.001). At logistic regression analysis, both miR\u2010155\u20105p (at baseline: OR\u2009=\u20094.52, p<\/jats:italic>\u2009=\u20090.022; at 6\u2009months: OR\u2009=\u20095.30, p<\/jats:italic>\u2009=\u20090.029) and HDV RNA (at baseline: OR\u2009=\u20090.19, p<\/jats:italic>\u2009=\u20090.022; at 6\u2009months: OR\u2009=\u20090.38, p<\/jats:italic>\u2009=\u20090.018) resulted significantly associated to virologic response. Considering that Peg\u2010IFN\u03b1 still has a relevant role in the treatment of patients with chronic hepatitis D infection, the assessment of EV miR\u2010155\u20105p may represent an additional valuable tool for the management of HDV patients undergoing Peg\u2010IFN\u03b1 treatment.<\/jats:p>","DOI":"10.1111\/jvh.14000","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T04:49:41Z","timestamp":1723438181000},"page":"771-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["MiRNome<\/scp> Profiling of Circulating Extracellular Vesicles in Patients With Chronic Hepatitis D Undergoing Pegylated Interferon Alpha Treatment"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0529-9481","authenticated-orcid":false,"given":"Gian\u00a0Paolo","family":"Caviglia","sequence":"first","affiliation":[{"name":"Liver Unit, Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Casalone","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit, Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Olivero","sequence":"additional","affiliation":[{"name":"Liver Unit, Department of Medical Sciences University of Turin Turin Italy"},{"name":"A.O.U. Citt\u00e0 della Salute e della Scienza Molinette Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Birolo","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit, Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Ciancio","sequence":"additional","affiliation":[{"name":"Liver Unit, Department of Medical Sciences University of Turin Turin Italy"},{"name":"A.O.U. Citt\u00e0 della Salute e della Scienza Molinette Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Matullo","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit, Department of Medical Sciences University of Turin Turin Italy"},{"name":"A.O.U. Citt\u00e0 della Salute e della Scienza Molinette Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Rizzetto","sequence":"additional","affiliation":[{"name":"Liver Unit, Department of Medical Sciences University of Turin Turin Italy"},{"name":"A.O.U. Citt\u00e0 della Salute e della Scienza Molinette Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2021.02.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2212151"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15410"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12121440"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku631"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2957"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14617"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S402524"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-354"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109775"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15112257"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108188"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2314134"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.14000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T07:28:11Z","timestamp":1729582091000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.14000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/jvh.14000"],"URL":"https:\/\/doi.org\/10.1111\/jvh.14000","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,11]]},"assertion":[{"value":"2024-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}