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Iron, a central co\u2010factor in various metabolic pathways, plays an essential role in liver function, but its dysregulation can lead to severe health consequences. Accumulation of iron within hepatic cells over time is linked to increased liver injury and is strongly associated with sensitive exposure to a range of conditions, including cirrhosis, fibrosis and ultimately, HCC. This review explores the intricate interplay between iron metabolism and HCC within the context of HBV infection. Hepatic iron overload can arise from liver injury and disruptions in iron homeostasis, causing hepatic necrosis, inflammation, and fibrosis, ultimately culminating in carcinogenesis. Moreover, alterations in serum iron components in HBV\u2010related scenarios have been observed to impact the persistence of HBV infection. Notably, the progression of HBV\u2010associated liver damage exhibits distinct characteristics at various stages of liver disease. In addition to elucidating the complex relationship between iron metabolism and HCC in the context of HBV infection, this review also investigates the prognostic implications of systemic iron levels for HCC. Furthermore, it aims to provide a comprehensive understanding of the intricate interplay between iron metabolism and HCC, extending the discussion to the context of hepatitis C virus (HCV) infection. By shedding light on these multifaceted connections, this review aims to contribute to our understanding of the pathogenesis of HBV\u2010associated HCC and potentially identify novel therapeutic avenues for intervention.<\/jats:p>","DOI":"10.1111\/jvh.14016","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T10:20:42Z","timestamp":1729765242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hepatitis B Virus\u2010Associated Liver Carcinoma: The Role of Iron Metabolism and Its Modulation"],"prefix":"10.1111","volume":"32","author":[{"given":"Imran","family":"Ali","sequence":"first","affiliation":[{"name":"Department of General Surgery, Subspecialty Hepatobiliary Surgery Shanxi First Medical Hospital Affiliated With Shanxi Medical University, Yangzi Qu  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoaib","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Urology First Hospital of Shanxi Medical University, Yangzi Qu  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Shah Zaman Haider","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences; Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxi","family":"Wei","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology Shanxi Medical University  Jing Zhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Yan","sequence":"additional","affiliation":[{"name":"Shandong University  Ji Nan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Fiaz","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Zoology Hazara University  Mansehra Khyber Pakhtunkhwa Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center First Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Subspecialty Hepatobiliary Surgery Shanxi First Medical Hospital Affiliated With Shanxi Medical University, Yangzi Qu  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3844-0592","authenticated-orcid":false,"given":"Wahid","family":"Shah","sequence":"additional","affiliation":[{"name":"Translational Medicine Research Center Shanxi Medical University  Taiyuan China"},{"name":"Shanxi Eye Hospital Affiliated to Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"669","volume-title":"Diseases of the Liver","author":"Tavill A. 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