{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:05:49Z","timestamp":1788879949299,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Clinical studies of tenofovir amibufenamide (TMF) and tenofovir alafenamide (TAF) treatment in patients with HBV\u2010related decompensated cirrhosis (HBV\u2010DC) are limited. This study evaluated the efficacy and safety of TMF versus TAF in naive\u2010treated patients with first\u2010time HBV\u2010DC. Based on the antiviral drug used, patients were categorised into the TMF group and the TAF group. Virological and serological responses, hepatic and renal functions and blood lipid changes in both groups were evaluated during 48\u2009weeks of treatment. A total of 98 patients were enrolled, 45 in the TMF group and 53 in the TAF group. At 48\u2009weeks of treatment, the proportions of patients who achieved complete virological response (CVR) were 85.7% and 90.7%, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.791). Improvement of at least 2 points in Child\u2013Turcotte\u2013Pugh scores was observed in 64.3% versus 79.1% (<jats:italic>p<\/jats:italic>\u2009=\u20090.169) of the patients. There were no significant changes in serum creatinine, estimated glomerular filtration rate or total cholesterol from baseline to week 48 between the two groups. Cystatin C remained stable in the TMF group but increased over time in the TAF group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Low\u2010density lipoprotein cholesterol remained stable in the TMF group but increased significantly in the TAF group at week 48 (<jats:italic>p<\/jats:italic>\u2009=\u20090.015). These results suggest that both TMF and TAF can rapidly suppress HBV replication, improve hepatic function and have no negative effects on renal function among patients with HBV\u2010DC. Regarding lipid metabolism, both showed a better safety, while regular monitoring of blood lipid levels is recommended.<\/jats:p>","DOI":"10.1111\/jvh.14029","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T10:46:25Z","timestamp":1730198785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and Safety of Tenofovir Amibufenamide and Tenofovir Alafenamide for First\u2010Time <scp>HBV<\/scp>\u2010Related Decompensated Cirrhosis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2108-5783","authenticated-orcid":false,"given":"Xinxin","family":"Rong","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangde","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-9458","authenticated-orcid":false,"given":"Xiucheng","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60207-5"},{"key":"e_1_2_8_3_1","first-page":"846","article-title":"Chinese Guidelines on the Management of Liver Cirrhosis (In Chinese)","volume":"27","author":"Chinese Society of Hepatology, Chinese Medical Association","year":"2019","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.11.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.04.063"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i40.4606"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.022"},{"key":"e_1_2_8_8_1","first-page":"1796","article-title":"Influencing Factors for Recompensation in Patients With First\u2010Time Decompensated Hepatitis B Cirrhosis (In Chinese)","volume":"38","author":"Ruan J. 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