{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:49:41Z","timestamp":1768535381790,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Despite available curative treatments, global rates of hepatitis C virus (HCV) infection persist with significant burden in low\u2010 and middle\u2010income countries (LMICs). Long\u2010acting (LA) antiviral products are in development. This study explored the challenges and opportunities in LA\u2010HCV treatment across three LMICs: Egypt, Ethiopia and India. The survey focused on understanding barriers and facilitators to treatment, with emphasis on LA treatment preferences. Four\u2010hundred respondents completed a survey including demographics, HCV treatment history and preferences for injections, implants and microarray patches (MAPs) compared to pills. Overall, 78% of respondents were willing to receive injections, 43% were willing to receive implants and 55% were willing to receive MAPs. Marked heterogeneity in acceptability of non\u2010oral treatments was observed. Among respondents who had not previously received HCV treatment, 94%, 43%, and 75% were willing to receive injections, implants, or MAPs, respectively. In contrast, among those already cured by oral HCV treatment, 61%, 40% and 43% were willing to receive injections, implants or MAPs. Other characteristics associated with willingness to receive an injection included urban residence, younger age, male sex, higher education level and taking pills for any reason (all results <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The most common concern for all LA modalities was lack of effectiveness. Prior experience with injection or implant increased willingness to receive any LA modality (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Coupled with a point\u2010of\u2010care HCV diagnostic test, availability of and willingness to receive HCV treatment delivered by a LA formulation could simplify and expand treatment access in LMICs and contribute towards global HCV elimination goals.<\/jats:p>","DOI":"10.1111\/jvh.14031","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T12:05:10Z","timestamp":1731672310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preferences and Feasibility of Long\u2010Acting Technologies for the Treatment of Hepatitis C Virus: A Survey of Patients in Diverse Low\u2010 and Middle\u2010Income Countries"],"prefix":"10.1111","volume":"32","author":[{"given":"Renae","family":"Furl","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine University of Nebraska Medical Center  Omaha Nebraska 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Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shruti","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Centre of Excellence in Long\u2010Acting Therapeutics (CELT) University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Rannard","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Centre of Excellence in Long\u2010Acting Therapeutics (CELT) University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Division of Clinical Pharmacology, Department of Medicine The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-6037","authenticated-orcid":false,"given":"Susan","family":"Swindells","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization \u201cAccelerating Access to Hepatitis C Diagnostics and Treatment: Overcoming Barriers in Low\u2010 and Middle\u2010Income Countries \u201dGlobal Progress Report 2020 (Geneva: World Health Organization 2021)."},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization \u201cGlobal Hepatitis Report 2017 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