{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:57:38Z","timestamp":1792648658054,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR133208"],"award-info":[{"award-number":["NIHR133208"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hepatitis C virus (HCV) is hypothesised to be a public health problem in Ethiopia, and systematic review evidence suggested 1%\u20133% seroprevalence. We aimed to estimate the seroprevalence of HCV overall and across regions of Ethiopia. We estimated HCV seroprevalence using the 2016 Ethiopian Demographic and Health Survey (EDHS\u20102016). EDHS\u20102016 is a nationwide household survey conducted using two\u2010stage cluster sampling methods. We tested all 26,753 samples from participating adult women (15\u201349\u2009years) and men (15\u201359\u2009years) using HCV Enzyme Immunoassay. Descriptive analyses were performed based on the Guide to Demographic Health Survey statistics. We applied sample weighting to derive representative estimates. Of the total tested, more than half (54.40%) were aged 15\u201329\u2009years and 51.59% were women. Overall HCV seroprevalence was 0.18% (95% Confidence Interval: 0.10\u20130.32). Higher seroprevalences were found in Afar (0.92%) and South Nations Nationality Peoples Region (0.43%); people living with HIV (PLWH) (0.62%); the poorest wealth index (0.35%); people having multiple lifetime sexual partners (0.31%); and widowed\/divorced individuals (0.30%). In stratified analyses by sex and residency, we found higher seroprevalences in non\u2010Christian and non\u2010Muslim males (1.98%) and rural population (1.00%), male PLWH (1.67%), rural PLWH (1.45%), widowed\/divorced males (0.97%), and in all groups from the Afar region: males (1.30%), females (0.61%), urban (1.07%), and rural (0.86%). HCV seroprevalence among the general population in Ethiopia is much lower than from previous estimates. General population screening is unlikely to be cost\u2010effective, and so screening programs targeted to people at greater risk of HCV will be required.<\/jats:p>","DOI":"10.1111\/jvh.14037","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T12:14:47Z","timestamp":1732191287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Seroprevalence of Hepatitis C in Ethiopia: First National Study Based on the 2016 Ethiopian Demographic and Health Survey"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9926-7797","authenticated-orcid":false,"given":"Getahun Molla","family":"Kassa","sequence":"first","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"},{"name":"Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1987-6996","authenticated-orcid":false,"given":"Atsbeha Gebreegziabxier","family":"Weldemariam","sequence":"additional","affiliation":[{"name":"Ethiopian Public Health Institute  Addis Ababa Ethiopia"},{"name":"Division of Molecular and Clinical Medicine, School of Medicine University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saro Abdella","family":"Abrahim","sequence":"additional","affiliation":[{"name":"Health Laboratory Services Ethiopian Public Health Institute  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6943-7353","authenticated-orcid":false,"given":"Clare E.","family":"French","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"},{"name":"NIHR Health Protection Research Unit in Behavioural Science and Evaluation at University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawit","family":"Wolday","sequence":"additional","affiliation":[{"name":"Ethiopian Public Health Institute  Addis Ababa Ethiopia"},{"name":"Department of Biochemistry &amp; Biomedical Sciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emebet","family":"Dagne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Health Jimma University  Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andargachew","family":"Mulu","sequence":"additional","affiliation":[{"name":"Armauer Hansen Research Institute  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aynishet","family":"Adane","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, College of Medicine and Health Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Inglis","sequence":"additional","affiliation":[{"name":"Tayside Clinical Trials Unit University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Radley","sequence":"additional","affiliation":[{"name":"Division of Public Health and Genomics, School of Medicine University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geremew","family":"Tasew","sequence":"additional","affiliation":[{"name":"Ethiopian Public Health Institute  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8291-5890","authenticated-orcid":false,"given":"Peter","family":"Vickerman","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias Ali","family":"Yesuf","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, Institute of Health Jimma University  Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ora","family":"Paltiel","sequence":"additional","affiliation":[{"name":"Department of Hematology and Braun School of Public Health Hadassah\u2010Hebrew University Faculty of Medicine  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mesay","family":"Hailu","sequence":"additional","affiliation":[{"name":"Ethiopian Public Health Institute  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wondwossen","family":"Amogne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Dillon","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine, School of Medicine University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-459X","authenticated-orcid":false,"given":"Matthew","family":"Hickman","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron G.","family":"Lim","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9732-5738","authenticated-orcid":false,"given":"Josephine G.","family":"Walker","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the DESTINE NIHR Global Health Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization \u201cGlobal Progress Report on HIV Viral Hepatitis and Sexually Transmitted Infections \u201d Accountability for the Global Health Sector Strategies 2016\u20132021: Actions for Impact (2021)."},{"key":"e_1_2_12_3_1","unstructured":"Ministry of Health\u2010Ethiopia \u201cNational Strategic Plan for Prevention and Control of Viral Hepatitis in Ethiopia 2021\u20132025 \u201d (2021) 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