{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:02:23Z","timestamp":1792839743633,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Acute hepatitis C (AHC) represents a considerable challenge to global public health, although direct\u2010acting antiviral (DAA) therapy has substantially improved therapeutic outcomes for hepatitis C virus infection. Data were exclusively obtained from the 2021 Global Burden of Disease (GBD) study, which examined trends in the burden of AHC in terms of incidence, mortality and disability\u2010adjusted life years (DALYs) across 204 countries and territories globally from 2009 to 2021. In 2021, there were 7,009,910.02 incident cases, 5474.37 deaths and 266,087.98 DALYs due to AHC. Between 1990 and 2021, the number of incident cases increased by 24.61%, whereas mortality and DALYs cases decreased by 45.66% and 46.57%, respectively. The age\u2010standardised incidence rate (ASIR), age\u2010standardised mortality rate (ASMR) and age\u2010standardised DALYs rate (ASDR) exhibited a declining trend. In 2021, the highest ASIRs of AHC were observed in Central Sub\u2010Saharan Africa and Central Asia. At a national level, Mongolia and Egypt reported the highest ASIRs in 2021. The ASIR of AHC was similar in males and females, while females had higher ASMR and ASDR than males. The highest ASIR was observed in children under 5\u2009years of age. Additionally, a negative association was found between the ASIR, ASMR, ASDR of AHC and sociodemographic index values at the regional and national levels. Our findings underscore the persistent severity of the global burden of AHC; effective and targeted strategies are needed to reduce the overall burden.<\/jats:p>","DOI":"10.1111\/jvh.70026","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T08:14:38Z","timestamp":1743322478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Global Burden and Trends of Acute Hepatitis C From 1990 to 2021: An Analysis Based on the 2021 Global Burden of Disease Study"],"prefix":"10.1111","volume":"32","author":[{"given":"Xinwei","family":"Wang","sequence":"first","affiliation":[{"name":"The Joint Laboratory on Transfusion\u2010Transmitted Diseases (TTDs) Between the Institute of Blood Transfusion, Chinese Academy of Medical Sciences, and Nanning Blood Center Nanning Blood Center  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xipeng","family":"Yan","sequence":"additional","affiliation":[{"name":"The Joint Laboratory on Transfusion\u2010Transmitted Diseases (TTDs) Between the Institute of Blood Transfusion, Chinese Academy of Medical Sciences, and Nanning Blood Center Nanning Blood Center  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoren","family":"He","sequence":"additional","affiliation":[{"name":"The Joint Laboratory on Transfusion\u2010Transmitted Diseases (TTDs) Between the Institute of Blood Transfusion, Chinese Academy of Medical Sciences, and Nanning Blood Center Nanning Blood Center  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"The Joint Laboratory on Transfusion\u2010Transmitted Diseases (TTDs) Between the Institute of Blood Transfusion, Chinese Academy of Medical Sciences, and Nanning Blood Center Nanning Blood Center  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linbin","family":"Huang","sequence":"additional","affiliation":[{"name":"The Joint Laboratory on Transfusion\u2010Transmitted Diseases (TTDs) Between the Institute of Blood Transfusion, Chinese Academy of Medical Sciences, and Nanning Blood Center Nanning Blood Center  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlian","family":"Li","sequence":"additional","affiliation":[{"name":"The Joint Laboratory on Transfusion\u2010Transmitted Diseases (TTDs) Between the Institute of Blood Transfusion, Chinese Academy of Medical Sciences, and Nanning Blood Center Nanning Blood Center  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongji","family":"Lai","sequence":"additional","affiliation":[{"name":"The Joint Laboratory on Transfusion\u2010Transmitted Diseases (TTDs) Between the Institute of Blood Transfusion, Chinese Academy of Medical Sciences, and Nanning Blood Center Nanning Blood Center  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshuang","family":"Lai","sequence":"additional","affiliation":[{"name":"The Joint Laboratory on Transfusion\u2010Transmitted Diseases (TTDs) Between the Institute of Blood Transfusion, Chinese Academy of Medical Sciences, and Nanning Blood Center Nanning Blood Center  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Xie","sequence":"additional","affiliation":[{"name":"The Xidian Group Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-3522","authenticated-orcid":false,"given":"Limin","family":"Chen","sequence":"additional","affiliation":[{"name":"The Joint Laboratory on Transfusion\u2010Transmitted Diseases (TTDs) Between the Institute of Blood Transfusion, Chinese Academy of Medical Sciences, and Nanning Blood Center Nanning Blood Center  Nanning China"},{"name":"The Xidian Group Hospital  Xi'an China"},{"name":"Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.012"},{"issue":"9","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"S782","DOI":"10.1093\/infdis\/jiaa096","article-title":"Hepatitis C Virus Treatment as Prevention: Challenges and Opportunities in Men Who Have Sex With Men","volume":"222","author":"Rockstroh J. 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