{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T05:03:32Z","timestamp":1764392612235,"version":"3.46.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hepatitis delta virus (HDV) and hepatitis B virus (HBV) co\u2010infection is considered a progressive chronic viral hepatitis where treatment options are limited and significant morbidity and mortality are prevalent. Studies have shown insufficient testing for HDV antibody (anti\u2010HDV) among HBV\u2010infected patients. Unlike European and Asian\u2010Pacific guidelines, the American Association for the Study of Liver Diseases (AASLD) guidelines recommend HDV testing only for high\u2010risk HBV patients. We evaluated the efficacy of universal vs. risk\u2010based screening in identifying HDV infection among HBV patients. We performed a retrospective analysis of patients diagnosed with a positive HBsAg in a tertiary medical center and screened for HDV between 2010 and 2022. 761 patients were found to be HBsAg\u2010positive. 525 (69%) patients met AASLD criteria for HDV screening (high\u2010risk) and 236 (31%) did not (low\u2010risk). Universal screening was performed on 559 (73.4%) patients. In the high\u2010risk group, anti\u2010HDV positivity was found in 33 patients (8.6%). 17 (51.5%) were found to be HDV RNA\u2010positive. In the low\u2010risk group, 4 (2.3%) were found to be anti\u2010HDV\u2010positive. None were found to be HDV RNA\u2010positive. Screening based on AASLD criteria identified only 89% of HDV antibody\u2010positive patients. During the study period, an increased rate of all\u2010cause mortality was observed in the AASLD high\u2010risk group. In this single\u2010center study, universal screening of HBsAg\u2010positive patients identified 11% more anti\u2010HDV\u2010positive patients in comparison to the AASLD\u2010supported high\u2010risk\u2010only screening recommendations. Due to the paramount importance of HDV detection, universal HDV screening in HBsAg\u2010positive patients is encouraged.<\/jats:p>","DOI":"10.1111\/jvh.70046","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T08:29:45Z","timestamp":1749630585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Universal Screening for\n                    <scp>HDV<\/scp>\n                    in\n                    <scp>HBV\u2010<\/scp>\n                    Infected Patients on Chronic\n                    <scp>HDV<\/scp>\n                    Detection Rate in Israel"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4078-7173","authenticated-orcid":false,"given":"David","family":"Yardeni","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Liver Diseases Soroka University Medical Center  Beersheba Israel"},{"name":"Joyce and Irving Goldman Medical School Faculty of Health Sciences  Beersheba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Cividalli","sequence":"additional","affiliation":[{"name":"Joyce and Irving Goldman Medical School Faculty of Health Sciences  Beersheba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Itkowitz","sequence":"additional","affiliation":[{"name":"Clinical Research Center Soroka University Medical Center  Beersheba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Lipnizkiy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Liver Diseases Soroka University Medical Center  Beersheba Israel"},{"name":"Joyce and Irving Goldman Medical School Faculty of Health Sciences  Beersheba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Abu","family":"Juma'a","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Liver Diseases Soroka University Medical Center  Beersheba Israel"},{"name":"Joyce and Irving Goldman Medical School Faculty of Health Sciences  Beersheba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4844-3308","authenticated-orcid":false,"given":"Naim","family":"Abufreha","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Liver Diseases Soroka University Medical Center  Beersheba Israel"},{"name":"Joyce and Irving Goldman Medical School Faculty of Health Sciences  Beersheba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayelet","family":"Keren\u2010Naus","sequence":"additional","affiliation":[{"name":"Joyce and Irving Goldman Medical School Faculty of Health Sciences  Beersheba Israel"},{"name":"Laboratory of Virology Services Soroka University Medical Center  Beersheba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadav","family":"Eisner","sequence":"additional","affiliation":[{"name":"Laboratory of Virology Services Soroka University Medical Center  Beersheba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anat Nevo","family":"Shor","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Liver Diseases Soroka University Medical Center  Beersheba Israel"},{"name":"Joyce and Irving Goldman Medical School Faculty of Health Sciences  Beersheba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ohad","family":"Etzion","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Liver Diseases Soroka University Medical Center  Beersheba Israel"},{"name":"Joyce and Irving Goldman Medical School Faculty of Health Sciences  Beersheba 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