{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T05:03:24Z","timestamp":1764392604000,"version":"3.46.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071604"],"award-info":[{"award-number":["82071604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hepatitis B virus (HBV) infection remains a global public health problem. To investigate whether HBV infection in women with different serostatus affects the outcomes of assisted reproductive technology (ART). This study included a total of 9891 infertile couples, comprising 1670 couples with HBV\u2010infected women and 8221 couples without HBV infection, all undergoing ART treatments during the same period. None of the male partners had chronic HBV infection. Three groups were defined: HBV\u2010positive, HBeAg\/preS1\u2010positive and HBV\u2010negative groups. Pregnancy outcomes were evaluated and compared using multivariate logistic regression analysis to control for confounding factors. Decreased rates of implantation, clinical pregnancy and live birth were observed in women with HBeAg\/preS1\u2010seropositive status. Following multivariate adjustment for potential confounders, the live birth and clinical pregnancy rates in the HBeAg\/preS1\u2010positive group were still significantly lower than those in the HBV\u2010negative group, with adjusted odds ratios of 0.86 (95% CI, 0.75\u20130.99) and 0.84 (95% CI, 0.73\u20130.96), respectively. No significant difference was observed between the HBV\u2010positive and HBV\u2010negative groups. Additionally, no differences were found in the miscarriage rate or preterm rate among the three groups. Women who were HBsAg\u2010 or HBeAg\/preS1\u2010seropositive exhibited a significantly higher incidence of secondary and tubal factor infertility compared to those without HBV infection. Overall HBV infection in women increases the risk of secondary infertility and tubal factor infertility, and female HBeAg\/preS1\u2010seropositive status adversely affects live birth and clinical pregnancy outcomes. The effect is likely attributed to the active HBV infection.<\/jats:p>","DOI":"10.1111\/jvh.70047","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T09:24:52Z","timestamp":1750325092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Assisted Reproductive Technology in Women With Hepatitis B Infection"],"prefix":"10.1111","volume":"32","author":[{"given":"Xiaoling","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang 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