{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T05:06:56Z","timestamp":1764392816552,"version":"3.46.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The combination of Sofosbuvir\/Velpatasvir(S\/V) is approved for the treatment of chronic HCV infection. In registrational trials, cure rates of 95% or more were achieved when administered as one pill per day for a period of 12\u2009weeks, regardless of genotype or disease stage. There is a need to develop and evaluate systems of care in populations excluded from clinical trials. We aim to evaluate the safety and efficacy of S\/V in a prospective study of HCV\u2010infected inner\u2010city residents enriched for risk behaviours for non\u2010adherence to therapy, including problematic drug use and unstable housing. Through dedicated outreach events, we identified HCV\u2010infected patients who were not currently engaged in health care and who were eligible to receive government\u2010funded antiviral treatment for HCV infection. We offered them the opportunity to enrol in a multidisciplinary programme of care to address medical, psychological, social, and addiction\u2010related needs, and provide S\/V therapy in this context, with enhanced supervision of adherence. We identified 222 eligible subjects, 31.5% female, median age of 47 (24\u201381) years. The most common genotype was 1, followed by 3 (48.2%, 38.7%) and 21.2% scored F3\u2010F4 FibroScan scores. 55.9% have unstable housing, and 98.6% are active drug users, with the majority utilising fentanyl, followed by amphetamines (82.9%, 64.9%). HCV treatment has been started in all 222 persons within a median of 6\u2009weeks of engagement in care. 218 persons completed treatment, one individual withdrew from the treatment, and 3 overdose deaths were documented. HCV cure was documented in 211\/218 (96.8%). Virologic relapse was documented in the other 7 cases. The intent\u2010to\u2010treat SVR rate of HCV treatment with S\/V was 211\/222 (95.0%). Taken together, our data validate the development of multidisciplinary programmes such as ours to address HCV infection, yielding high rates of engagement and retention in care, promoting initiation of treatment (usually within 6\u2009weeks) and\u2009&gt;\u200997% rate of cure.<\/jats:p>","DOI":"10.1111\/jvh.70057","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T08:33:47Z","timestamp":1752914027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CHIME<\/scp>\n                    : Sofosbuvir\/Velpatasvir (S\/V) for the Treatment of\n                    <scp>HCV<\/scp>\n                    Infection Among Vulnerable Inner\u2010City Residents"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9930-7587","authenticated-orcid":false,"given":"Brian","family":"Conway","sequence":"first","affiliation":[{"name":"Vancouver Infectious Diseases 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